Results 161 to 170 of about 59,474 (295)

Groundwater Microbial Diversity Associated With Icelandic Basaltic Subsurface Environments

open access: yesEnvironmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Overview of microbial diversity and environmental drivers in Icelandic deep basaltic aquifers. Using 16S rRNA gene metabarcoding across 22 geothermal wells spanning broad temperature, pH, and bedrock‐age gradients, the study reveals distinct bacterial and archaeal community structures shaped by temperature, pH, and host‐rock reactivity.
Juliette Bas‐Lorillot   +11 more
wiley   +1 more source

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 24, Page 6063-6080, December 2025.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce   +25 more
wiley   +1 more source

From cells to pixels: A decision tree for designing bioimage analysis pipelines

open access: yesJournal of Microscopy, Volume 300, Issue 3, Page 384-408, December 2025.
Abstract Bioimaging has transformed our understanding of biological processes, yet extracting meaningful information from complex datasets remains a challenge, particularly for biologists without computational expertise. This paper proposes a simple general approach, to help identify which image analysis methods could be relevant for a given image ...
Elnaz Fazeli   +4 more
wiley   +1 more source

The Chemical Evolution of Galaxy Disks

open access: yes, 2000
We discuss the main ingredients necessary to build models of chemical evolution of spiral galaxies and in particular the Milky Way galaxy. These ingredients include: the star formation rate, the initial mass function, the stellar yields and the gas flows.
openaire   +2 more sources

Climate Emergency and Different Ways to Fail? The Fermi Paradox, the Simulation Hypothesis, Agency and Hope

open access: yesJournal for the Theory of Social Behaviour, Volume 55, Issue 4, December 2025.
ABSTRACT Humanity seems stuck on different ways to fail to meet the challenge posed by a declared climate emergency and manifest the problems of ecological breakdown. Rather than reprise these failures, we use the Fermi Paradox and simulation hypothesis to make a simple point about agency. The argument unfolds in two sections.
Jamie Morgan
wiley   +1 more source

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