Results 121 to 130 of about 27,415 (188)

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice

Cell & Bioscience
Background In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor ...
Fangli Shan, Jianan Ye, Xinzhong Xu, Chao Liang, Yuanzhe Zhao, Jingwen Wang, Fangru Ouyang, Jianjian Li, Jianwei Lv, Zhonghan Wu, Fei Yao, Juehua Jing, Meige Zheng   +12 more
doaj   +1 more source

Galectin-3-Binding Protein [PDF]

, 2020
openaire   +1 more source

Scrutinising the Conformational Ensemble of the Intrinsically Mixed-Folded Protein Galectin-3

Molecules
Galectin-3 is a protein involved in many intra- and extra-cellular processes. It has been identified as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease and cancer.
Midhun Mohan Anila, Paweł Rogowski, Bartosz Różycki   +2 more
doaj   +1 more source

Galectin 3-binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein. [PDF]

J Biol Chem, 2020
Seki T, Kanagawa M, Kobayashi K, Kowa H, Yahata N, Maruyama K, Iwata N, Inoue H, Toda T.   +8 more
europepmc   +1 more source

The Galectin-3-binding protein promotes angiogenesis in pancreatic cancer via simultaneous upregulation of VEGFA and direct HUVEC activation mediated by and VAMP5-STAT3. [PDF]

Cell Commun Signal
Lim YJ, Son DW, Lee EJ, Yu CW, Oh YO, Cha MJ, Kim H, Kim K, Chang S.   +8 more
europepmc   +1 more source

Galectin 3-binding protein suppresses PRRSV replication via Cullin3-mediated ubiquitination degradation of non-structural protein 12. [PDF]

J Virol
Wang X, Zhang W, Zhang J, Li R, Zhang L, Yan N, Zhu J, Fu L, Wang Y.   +8 more
europepmc   +1 more source

Galectin 3-binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1 (TGF-β1) availability and inhibits hepatocarcinogenesis. [PDF]

Cancer Commun (Lond)
Kim DH, Sung M, Park MS, Sun EG, Yoon S, Yoo KH, Radhakrishnan K, Jung SY, Bae WK, Cho SH, Chung IJ.   +10 more
europepmc   +1 more source

Spectral library-based glycopeptide analysis-detection of circulating galectin-3 binding protein in pancreatic cancer. [PDF]

Proteomics Clin Appl, 2017
Nigjeh EN, Chen R, Allen-Tamura Y, Brand RE, Brentnall TA, Pan S.   +5 more
europepmc   +1 more source

Galectin-3 and galectin-3 binding protein in rheumatoid arthritis

, 2003
Ohshima, S, Kuchen, S, Seemayer, C, Liu, FT, Neidhart, M, Gay, RE, Gay, S   +6 more
openaire   +1 more source