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Revealing the Identity of Human Galectin-3 as a Glycosaminoglycan-Binding Protein

2022
Human galectin-3 (Gal-3) is a β-galactoside-binding lectin. This multitasking protein preferentially interacts with N-acetyllactosamine moieties on glycoconjugates. Specific hydroxyl groups (4-OH, 6-OH of galactose, and 3-OH of glucose/N-acetylglucosamine) of lactose/LacNAc are essential for their binding to Gal-3.
Jared L, Edwards   +3 more
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Galectin-3 Is a Nuclear Matrix Protein Which Binds RNA

Biochemical and Biophysical Research Communications, 1995
The endogenous galectin-3 is a carbohydrate-binding protein of M(r) approximately 30,000 serving in the cytoplasm and on the cell surface as a receptor for ligands containing poly-N-acetyllactosamine sequences. In addition, galectin-3 has been demonstrated to be associated in the nucleus with ribonucleoprotein complexes and to act as a pre-mRNA ...
L, Wang, H, Inohara, K J, Pienta, A, Raz
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Galectin-3-binding protein is a novel predictor of venous thromboembolism in systemic lupus erythematosus

Clinical and Experimental Rheumatology, 2021
Venous (VTE) and arterial (AT) thrombosis in systemic lupus erythematosus (SLE) are poorly explained and difficult to predict. Leptin and tumour necrosis factor-like weak inducer of apoptosis (TWEAK) have been linked to subclinical atherosclerosis and galectin-3-binding protein (G3BP) to type I interferon activation and a pro-thrombotic environment ...
Peretz, Anne Sofie R.   +4 more
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