Results 151 to 160 of about 43,794 (228)

Engagement of a Neighboring Lys Residue by a Salicylaldehyde‐Modified Glycomimetic Ligand Enables Potent and Selective Binding to DC‐SIGN Over L‐SIGN

ChemistryEurope, Volume 4, Issue 5, May 2026.
Mannose derivatives connected to the aminophilic salicylaldehyde tag show high binding affinity for C‐type lectin DC‐SIGN, favored by an imine bond with a protein's Lys residue in the ligand binding site. This reversible‐covalent binding interaction enables ligand selectivity for DC‐SIGN over the closely related L‐SIGN.
Sara Pollastri, Clara Delaunay, Giulia Antonini, Carine Froment, Michel Thépaut, Davide Pasquali, Sarah Mazzotta, Laura Belvisi, Julien Marcoux, Franck Fieschi, Alberto Dal Corso, Anna Bernardi   +11 more
wiley   +1 more source

Plasma-Derived Extracellular Vesicles Reveal Galectin-3 Binding Protein as Potential Biomarker for Early Detection of Glioma. [PDF]

Front Oncol, 2021
Rana R, Chauhan K, Gautam P, Kulkarni M, Banarjee R, Chugh P, Chhabra SS, Acharya R, Kalra SK, Gupta A, Jain S, Ganguly NK.   +11 more
europepmc   +1 more source

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X‐Inactivation Features

Aging Cell, Volume 25, Issue 5, May 2026.
Loss of chromosome Y in male leukocytes exhibits cell type‐specific effects on immune cell phenotypes and transcriptional profiles along differentiation trajectories. LOY is associated with profibrotic monocyte signatures and aberrant X‐inactivation gene expression, highlighting links to immune dysfunction and age‐related diseases in men.
Ahmed Dawoud, Luke Green, Owen Rackham
wiley   +1 more source

Curcumin – A Potent Inhibitor of Galectin-3 Expression

Food Technology and Biotechnology, 2002
The expression of galectin-3, a b-galactoside binding lectin, was found to be affected by different kinds of stressors, and is strongly modified in numerous physiological and pathophysiological conditions.
Jerka Dumić, Sanja Dabelić, Mirna Flögel   +2 more
doaj  

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice

Cell & Bioscience
Background In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor ...
Fangli Shan, Jianan Ye, Xinzhong Xu, Chao Liang, Yuanzhe Zhao, Jingwen Wang, Fangru Ouyang, Jianjian Li, Jianwei Lv, Zhonghan Wu, Fei Yao, Juehua Jing, Meige Zheng   +12 more
doaj   +1 more source

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal–Fetal Tolerance

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao, Li Zou, Yao Yao, Changling Liu   +3 more
wiley   +1 more source

Characterization of the Human Blood Group Glycosyltransferases GTA and GTB for the Synthesis of Blood Group Antigens

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
This study presents the highly efficient heterologous production of the human blood group glycosyltransferases GTA/R176A and GTB, along with their comprehensive biochemical and kinetic characterization. Tailored enzyme cascades, involving the bacterial fucosyltransferase FutC and GTA or GTB, generate milligram quantities of various blood group ABH ...
Katja Pöstges, Philip Palm, Kai P. Hussnaetter, Eliška Filipová, Helena Pelantová, Lucie Petrásková, Pavla Bojarová, Vladimír Křen, Lothar Elling   +8 more
wiley   +1 more source

Galectin-3-Binding Protein [PDF]

, 2020
openaire   +1 more source