Results 1 to 10 of about 18,892,704 (362)
Journal of Medicinal Chemistry, 2022 Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which currently is in clinical
F. Zetterberg +13 more
semanticscholar +1 more source
Emerging roles of Galectin-3 in diabetes and diabetes complications: A snapshot
Reviews in Endocrine & Metabolic Disorders, 2022 Galectin-3 is a member of the galectin family, widely expressed in immune cells and plays a role mainly in inflammation, autoimmunity, apoptosis, and chemotaxis.
Yanhua Li +3 more
semanticscholar +1 more source
Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. [PDF]
PLoS ONE, 2014 Patients with primary aldosteronism are associated with increased myocardial fibrosis. Galectin-3 is one of the most important mediators between macrophage activation and myocardial fibrosis.To investigate whether aldosterone induces galectin-3 secretion
Yen-Hung Lin +11 more
doaj +1 more source
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
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Nature Communications, 2022 How the carbohydrate binding protein galectin-3 might act as a diabetogenic and tumorogenic factor remains to be investigated. Here we report that intracellular galectin-3 interacts with Rag GTPases and Ragulator on lysosomes.
Xing Chen +14 more
semanticscholar +1 more source
Biomolecules, 2022 Galectin-3 is the only chimeric representative of the galectin family. Although galectin-3 has ubiquitous regulatory and physiological effects, there is a great number of pathological environments where galectin-3 cooperatively participates.
Lucas de Freitas Pedrosa +2 more
semanticscholar +1 more source
Current Issues in Molecular Biology, 2023 Numerous studies have considered galectin-3 or Glycogen synthase kinase 3 beta (GSK3B) as a potential prognosis marker for various cancers. However, the correlation between the protein expression of galectin-3/GSK3B and the clinical parameters of ...
Hung-Pei Tsai +6 more
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The Diagnostic and Therapeutic Potential of Galectin-3 in Cardiovascular Diseases
Biomolecules, 2021 Galectin-3 plays a prominent role in chronic inflammation and has been implicated in the development of many disease conditions, including heart disease.
G. Sygitowicz +2 more
semanticscholar +1 more source
Twist1 regulates macrophage plasticity to promote renal fibrosis through galectin-3
Cellular and Molecular Life Sciences, 2021 Renal interstitial fibrosis is the pathological basis of end-stage renal disease, in which the heterogeneity of macrophages in renal microenvironment plays an important role.
Qingfeng Wu +13 more
semanticscholar +1 more source
Galectin-3 as prognostic biomarker in patients with COVID-19 acute respiratory failure
Respiratory Medicine, 2021 Objectives Galectin-3 is β-galactoside-binding lectin with several roles in immune-inflammatory response. To date, there is no evidence of Galectin-3 role as a prognostic biomarker in COVID-19 disease.
Andrea Portacci +6 more
semanticscholar +1 more source