Results 21 to 30 of about 18,236,139 (292)

Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats [PDF]

Clinical and Molecular Hepatology, 2022
Background/Aims Galectin-3 plays a key pathogenic role in cardiac hypertrophy and heart failure. The present study aimed to investigate the effects of galectin-3 on cardiomyopathy – related factors and cardiac contractility in a rat model of cirrhotic ...
Ki Tae Yoon, Hongqun Liu, Jing Zhang, Sojung Han, Samuel S. Lee   +4 more
doaj   +1 more source

Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]

, 2002
The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Holíkova, Zuzana, Kaltner, Herbert, Motlik, Jan, Gabius, Hans-Joachim, Plzák, Jan, Smetana, Karel, Hercogová, Jana, Dvorankova, Barbora   +7 more
core   +1 more source

Intensity and Grading of Galectin-3 Expression as a Sole Marker to Differentiate Benign and Malignant Thyroid Neoplasms

National Journal of Laboratory Medicine, 2019
Introduction: Errors in categorization of thyroid neoplasms as benign or malignant has management implications. In several studies Galectin-3 was one of the most reliable markers for malignancy in thyroid.
Pallavi Vijay Borkar, Kondisetty Gowrinath, Kondisetty Sandeep   +2 more
doaj   +1 more source

Upregulation of galectin-3 in influenza A virus infection promotes viral RNA synthesis through its association with viral PA protein

Journal of Biomedical Science, 2023
Background Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of the PA, PB1, and PB2 subunits, and the amino acid residues of each subunit are highly conserved among influenza A virus ...
Mei-Lin Yang, Yi-Cheng Chen, Chung-Teng Wang, Hao-Earn Chong, Nai-Hui Chung, Chia-Hsing Leu, Fu-Tong Liu, Michael M. C. Lai, Pin Ling, Chao-Liang Wu, Ai-Li Shiau   +10 more
doaj   +1 more source

The role of galectin-3 and galectin-3–binding protein in venous thrombosis [PDF]

Blood, 2015
Key PointsWe determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.
Elise P, DeRoo, Shirley K, Wrobleski, Evelyn M, Shea, Ramsey K, Al-Khalil, Angela E, Hawley, Peter K, Henke, Daniel D, Myers, Thomas W, Wakefield, Jose A, Diaz   +8 more
openaire   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Circulating Galectin-3 Evaluation in Dogs With Cardiac and Non-cardiac Diseases

Frontiers in Veterinary Science, 2021
Galectin-3 is involved in important biological functions such as fibrogenesis and inflammation. Notably, it is associated with various diseases and plays a major role in cardiac inflammation and fibrosis.
Ga-Won Lee, Min-Hee Kang, Woong-Bin Ro, Doo-Won Song, Hee-Myung Park   +4 more
doaj   +1 more source

The Role of Galectin-3 in the Kidneys [PDF]

International Journal of Molecular Sciences, 2016
Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During development, it promotes
Szu-Chia Chen, Po-Lin Kuo
openaire   +2 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer [PDF]

, 2003
Galectin-3 is an apoptosis-related gene previously found to be over-expressed in invasive tumours and to cause in v itroinvasiveness and metastasis in colon, breast and thyroid follicular cancer cells.
Linehan, Rasha
core   +2 more sources