Results 41 to 50 of about 18,892,704 (362)

Galectin-3 and the skin [PDF]

Journal of Dermatological Science, 2011
Galectin-3 is highly expressed in epithelial cells including keratinocytes and is involved in the pathogenesis of inflammatory skin diseases by affecting the functions of immune cells. For example, galectin-3 can contribute to atopic dermatitis (AD) by promoting polarization toward a Th2 immune response by regulating dendritic cell (DC) and T cell ...
Larissa, Larsen, Huan-Yuan, Chen, Jun, Saegusa, Fu-Tong, Liu   +3 more
openaire   +2 more sources

Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells [PDF]

, 2017
The galactoside-binding protein galectin-3 is increasingly recognized as an important player in cancer development, progression, and metastasis via its interactions with various galactoside-terminated glycans.
Beynon, R, Colomb, F, Rhodes, JM, Simpson, D, Wang, W, Yu, LG, Zafar, M   +6 more
core   +1 more source

Human galectin-1 and galectin-3 promote Tropheryma whipplei infection [PDF]

Gut Microbes, 2021
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple's disease. The bacterium infects and replicates in macrophages, leading to a Th2-biased immune response. Previous studies have shown that T. whipplei harbors complex surface glycoproteins with evidence of sialylation. However, the exact contribution
Ayona, Diyoly, Zarza, Sandra Madariaga, Landemarre, Ludovic, Roubinet, Benoît, Decloquement, Philippe, Raoult, Didier, Fournier, Pierre-Edouard, Desnues, Benoit   +7 more
openaire   +4 more sources

Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation

Frontiers in Molecular Neuroscience, 2017
Galectin-3, a member of the galectin protein family, has been found to regulate cell proliferation, inhibit apoptosis and promote inflammatory responses.
Yan-Chu Chen, Yun-Li Ma, Cheng-Hsiung Lin, Sin-Jhong Cheng, Sin-Jhong Cheng, Wei-Lun Hsu, Eminy H.-Y. Lee, Eminy H.-Y. Lee   +7 more
doaj   +1 more source

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Altschuler Y., Gabius H.J., Gendler S., Gouyer V., Hennebicq-Reig S., Huang J., Ligtenberg M.J., Ninomiya H., Yamashita K.   +8 more
core   +3 more sources

Circulating Galectin-3 Evaluation in Dogs With Cardiac and Non-cardiac Diseases

Frontiers in Veterinary Science, 2021
Galectin-3 is involved in important biological functions such as fibrogenesis and inflammation. Notably, it is associated with various diseases and plays a major role in cardiac inflammation and fibrosis.
Ga-Won Lee, Min-Hee Kang, Woong-Bin Ro, Doo-Won Song, Hee-Myung Park   +4 more
doaj   +1 more source

Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1

Frontiers in Cell and Developmental Biology, 2019
Galectin-3 (encoded by LGALS3) is a glycan-binding protein that regulates a diverse range of pathophysiological processes contributing to the pathogenesis of human diseases. Previous studies have found that galectin-3 levels are up-regulated in the liver
Zilong Li, Fangqiao Lv, Congxin Dai, Qiong Wang, Chao Jiang, Mingming Fang, Mingming Fang, Yong Xu, Yong Xu   +8 more
doaj   +1 more source

Upregulation of galectin-3 in influenza A virus infection promotes viral RNA synthesis through its association with viral PA protein

Journal of Biomedical Science, 2023
Background Influenza is one of the most important viral infections globally. Viral RNA-dependent RNA polymerase (RdRp) consists of the PA, PB1, and PB2 subunits, and the amino acid residues of each subunit are highly conserved among influenza A virus ...
Mei-Lin Yang, Yi-Cheng Chen, Chung-Teng Wang, Hao-Earn Chong, Nai-Hui Chung, Chia-Hsing Leu, Fu-Tong Liu, Michael M. C. Lai, Pin Ling, Chao-Liang Wu, Ai-Li Shiau   +10 more
doaj   +1 more source

Biomarkers and low risk in heart failure. Data from COACH and TRIUMPH [PDF]

, 2015
Aim Traditionally, risk stratification in heart failure (HF) emphasizes assessment of high risk. We aimed to determine if biomarkers could identify patients with HF at low risk for death or HF rehospitalization.
Anand, Behnes, Boer, Boer, Boer, Boer, Chen, Cheng, Christenson, De Boer, DeLong, Edelmann, Fonarow, Fonarow, Gheorghiade, Grafft, Jaarsma, Jaarsma, Jencks, Kimmenade, Levy, Lok, Maisel, Marti, Masson, Meijers, Meijers, Motiwala, O'Brien, O'Connor, Ouwerkerk, Peacock, Pencina, Phillips, Postmus, Rahimi, Ruifrok, Salah, Setoguchi, Sharma, Stewart, Troughton, Vazquez, Velde, Veldhuisen, Yancy, Yu   +46 more
core   +1 more source

Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1).

PLoS ONE, 2011
BackgroundGalectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the
Seok-Jun Kim, Ji-Young Shin, Kang-Duck Lee, Young-Ki Bae, Il-Ju Choi, Seok Hee Park, Kyung-Hee Chun   +6 more
doaj   +1 more source