Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]
, 2012 C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira +39 more
core +5 more sources
The therapeutic potential of galectin-3 inhibition in fibrotic disease.
International Journal of Biochemistry and Cell Biology, 2020 Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a C-terminal carbohydrate recognition domain (CRD) linked to a proline ...
R. Slack, R. Mills, A. MacKinnon
semanticscholar +1 more source
Galectin-3 Modulates Experimental Colitis [PDF]
Digestion, 2015 Background: We recently identified galectin-3 (gal-3) as a new and strong fibroblast activator produced by colonic epithelial cells. Very little is known about the influence of gal-3 in inflammatory bowel disease. We, therefore, investigated the impact of gal-3 on dextran sodium sulfate (DSS)-induced colitis in a mouse model.
Lippert, Elisabeth +5 more
openaire +3 more sources
NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration
Frontiers in Cellular Neuroscience, 2020 Microglia are brain macrophages that mediate neuroinflammation and contribute to and protect against neurodegeneration. The terminal sugar residue of all glycoproteins and glycolipids on the surface of mammalian cells is normally sialic acid, and ...
M. Puigdellívol +2 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
The two endocytic pathways mediated by the carbohydrate recognition domain and regulated by the collagen-like domain of galectin-3 in vascular endothelial cells. [PDF]
PLoS ONE, 2012 Galectin-3 plays an important role in endothelial morphogenesis and angiogenesis. We investigated the endocytosis of galectin-3 in human vascular endothelial cells and showed that galectin-3 could associate with and internalized into the cells in a ...
Xiaoge Gao +7 more
doaj +1 more source
Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis [PDF]
, 2017 Background: Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the clinical variables would improve ...
Hanah Kim +5 more
core +2 more sources
Galectin-3 Is a Potential Mediator for Atherosclerosis
Journal of Immunological Research, 2020 Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke.
Ziyu Gao +5 more
semanticscholar +1 more source
Galectins, antibodies to them and galectin-3 binding protein in systemic lupus erythematosus
Научно-практическая ревматологияThe study of galectins is provoked by the search for new biomarkers of activity, clinical manifestations, and disease outcomes of systemic lupus erythematosus (SLE). The presented literature review summarizes the data on the most well-known galectins-1, -
L. V. Kondratyeva +2 more
doaj +1 more source