Results 61 to 70 of about 18,236,139 (292)

The Relationship between Serum Galectin-3 and Serum Markers of Cardiac Extracellular Matrix Turnover in Heart Failure Patients

, 2011
Background: A growing body of evidence links macrophage activation and fibrosis to the pathogenesis of heart failure (HF). Galectin-3 is one of the most likely mediators between macrophage activation and myocardial fibrosis.
LIN, YEN-HUNG;LIN, LIAN-YU;WU, YEN-WEN;CHIEN, KUO-LIONG;LEE, CHII-MING;HSU, RON-BIN;CHAO, CHIA-LUN;WANG, SHOEI-SHEN;HSEIN, YENH-CHEN;LIAO, LIN-CHU;HO, YI-LWUN;CHEN, MING-FONG, 林彥宏;林亮宇;吳彥雯;簡國龍;李啟明;許榮彬;趙嘉倫;王水深;謝月貞;廖玲巧;何奕倫;陳明豐   +1 more
core   +1 more source

Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice [PDF]

, 2013
PMCID: PMC3579848This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Karla J. Castellanos (7918193), Perretti, M, Akasheh, RT, Mauro Perretti (241694), Rand T Akasheh, Jingbo Pang, Jingbo Pang (381396), Pini, M, Castellanos Karla J., Dianne Cooper, Davina H Rhodes, Mauro Perretti, Rhodes Davina H., Giamila Fantuzzi (315958), Fantuzzi, G, Fantuzzi Giamila, Cabay Robert J., Davina H. Rhodes (315954), Rand T. Akasheh (7918190), Cooper Dianne, Cabay, RJ, Pang Jingbo, Robert J. Cabay (7918196), Maria Pini (315953), Robert J Cabay, Pini Maria, Castellanos, KJ, Karla J Castellanos, Rhodes, DH, Maria Pini, Akasheh Rand T., Dianne Cooper (381398), Cooper, D, Giamila Fantuzzi, Pang, J, Perretti Mauro   +35 more
core   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection.

PLoS Pathogens, 2020
Aspergillus fumigatus is an opportunistic mold that infects patients who are immunocompromised or have chronic lung disease, causing significant morbidity and mortality in these populations. While the factors governing the host response to A.
Brendan D Snarr, Guillaume St-Pierre, Benjamin Ralph, Mélanie Lehoux, Yukiko Sato, Ann Rancourt, Takahiro Takazono, Shane R Baistrocchi, Rachel Corsini, Matthew P Cheng, Michele Sugrue, Lindsey R Baden, Koichi Izumikawa, Hiroshi Mukae, John R Wingard, Irah L King, Maziar Divangahi, Masahiko S Satoh, Bryan G Yipp, Sachiko Sato, Donald C Sheppard   +20 more
doaj   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

The Expression of Galectin-3 in Tumor and Cancer-Associated Fibroblasts in Invasive Micropapillary Breast Carcinomas: Relationship with Clinicopathologic Parameters

European Journal of Breast Health, 2021
Objective:Galectin-3 affects tumor progression and cell surface polarization by expressing from the tumor and cancer-associated fibroblasts (CAFs). Therefore, it may have a role on micropapillary carcinomas (IMPC), which have characteristic morphological
Yasemin Çakır, Canan Kelten Talu, Özlem Mermut, Didem Can Trabulus, Esra Arslan   +4 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis

Frontiers in Veterinary Science, 2018
Galectins are potent regulators of cell adhesion, growth and apoptosis in diverse cell types, including chondrocytes and synovial fibroblasts. Elevations in synovial fluid galectin-3 have been observed in rheumatoid arthritis, juvenile idiopathic ...
Heidi L. Reesink, Alan J. Nixon, Jin Su, Sherry Liu, Ryan M. Sutton, Sabine Mann, Ashlee E. Watts, Ryan P. Peterson   +7 more
doaj   +1 more source

Immunoprecipitation of spliceosomal RNAs by antisera to galectin-1 and galectin-3 [PDF]

Nucleic Acids Research, 2006
We have shown that galectin-1 and galectin-3 are functionally redundant splicing factors. Now we provide evidence that both galectins are directly associated with spliceosomes by analyzing RNAs and proteins of complexes immunoprecipitated by galectin-specific antisera.
Wang, Weizhong, Park, Jung W., Wang, John L., Patterson, Ronald J.   +3 more
openaire   +2 more sources