Results 71 to 80 of about 18,892,704 (362)

Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

PLoS ONE, 2013
Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette (ABC) transporters and induction of galectin-3 signaling. Galectin-3 plays an anti-apoptotic role
Yung-Kuo Lee, Tsung-Hsien Lin, Chuan-Fa Chang, Yu-Li Lo   +3 more
doaj   +1 more source

Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]

, 2018
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
core   +1 more source

Galectin-3: A Potential Prognostic and Diagnostic Marker for Heart Disease and Detection of Early Stage Pathology

Biomolecules, 2020
The use of molecular biomarkers for the early detection of heart disease, before their onset of symptoms, is an attractive novel approach. Ideal molecular biomarkers, those that are both sensitive and specific to heart disease, are likely to provide a ...
A. Hara, M. Niwa, Tomohiro Kanayama, Kei Noguchi, Ayumi Niwa, Mikiko Matsuo, Takahiro Kuroda, Y. Hatano, Hideshi Okada, H. Tomita   +9 more
semanticscholar   +1 more source

Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes [PDF]

, 2017
Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors may reduce cardiovascular and heart failure risk in patients with type 2 diabetes mellitus (T2DM).
Butler, Javed, Davies, Michael J., Desai, Mehul, Januzzi, James L., Jarolim, Petr, Sattar, Naveed, Vijapurkar, Ujjwala   +6 more
core   +1 more source

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients with Nonalcoholic Steatohepatitis With Cirrhosis And Portal Hypertension.

Gastroenterology, 2019
BACKGROUND & AIMS Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contributes to toxin-induced liver fibrosis in mice.
N. Chalasani, M. Abdelmalek, G. Garcia‐Tsao, R. Vuppalanchi, N. Alkhouri, M. Rinella, M. Noureddin, Maxmillan Pyko, M. Shiffman, A. Sanyal, A. Allgood, H. Shlevin, Rex Horton, E. Zomer, W. Irish, Z. Goodman, Stephen Harrison, P. Traber, M. Abdelmalek, L. Balart, B. Borg, M. Charlton, H. Conjeevaram, M. Fuchs, R. Ghalib, P. Gholam, D. Halegoua-De Marzio, Stephen Harrison, Christopher Jue, N. Kemmer, K. Kowdley, M. Lai, E. Lawitz, R. Loomba, A. Paredes, M. Rinella, D. Rockey, Miguel J. Rodríguez, R. Rubin, M. Ryan, A. Scanga, T. Sepe, B. Tetri, P. Thuluvath, D. Torres, J. Vierling, J. Wattacheril, A. Weiland, D. Zogg   +48 more
semanticscholar   +1 more source

Galectin-3 Identifies a Subset of Macrophages With a Potential Beneficial Role in Atherosclerosis

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Galectin-3 (formerly known as Mac-2), encoded by the LGALS3 gene, is proposed to regulate macrophage adhesion, chemotaxis, and apoptosis.
K. Di Gregoli, M. Somerville, Rosaria Bianco, Anita C. Thomas, Aleksandra Frankow, A. Newby, S. George, C. Jackson, Jason L. Johnson   +8 more
semanticscholar   +1 more source

Galectin-3 Binding and Metastasis [PDF]

, 2003
Galectin-3 (gal-3) is a member of a growing family of carbohydrate-binding proteins. It consists of two functional domains: an amino-(N)-terminal domain, which is cleavable by collagenases and is responsible for dimerization as well as secretion of the protein, and a carboxy-(C)-terminal domain with affinity for carbohydrates containing N ...
Pratima, Nangia-Makker, Vitaly, Balan, Avraham, Raz   +2 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3

Bioengineering, 2017
Galectin inhibitor design is an emerging research field due to the involvement of galectins in cancer. Galectin-3, in particular, plays an important role in tumor progression.
Sophia Böcker, Lothar Elling
doaj   +1 more source

Could Galectin 3 Be a Good Prognostic Factor in Endometrial Cancer?

Diagnostics, 2020
Galectin 3 is a modulator of several basic biological functions. It may be involved in the development of obesity and type 2 diabetes—risk factors of endometrial cancer.
Aneta Cymbaluk-Płoska, Paula Gargulińska, Sebastian Kwiatkowski, Ewa Pius-Sadowska, Bogusław Machaliński   +4 more
doaj   +1 more source