Results 81 to 90 of about 18,892,704 (362)

The Expression of Galectin-3 in Tumor and Cancer-Associated Fibroblasts in Invasive Micropapillary Breast Carcinomas: Relationship with Clinicopathologic Parameters

European Journal of Breast Health, 2021
Objective:Galectin-3 affects tumor progression and cell surface polarization by expressing from the tumor and cancer-associated fibroblasts (CAFs). Therefore, it may have a role on micropapillary carcinomas (IMPC), which have characteristic morphological
Yasemin Çakır, Canan Kelten Talu, Özlem Mermut, Didem Can Trabulus, Esra Arslan   +4 more
doaj   +1 more source

β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors. [PDF]

Chembiochem
Galacto‐mimicking mannosyl monotriazoles, but not bis‐triazoles, inhibit galectin‐3 and galectin‐9 N‐terminal domain. Mannosyl β‐C‐1 amidotriazoles have previously been reported to have higher selectivity for galectin‐9N (N‐terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin‐3.
Sjövall F, Nilsson UJ.
europepmc   +2 more sources

Artificial Intelligence in Systemic Sclerosis: Clinical applications, challenges, and future directions

Arthritis Care &Research, Accepted Article.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

TGFβ Suppresses Galectin-3 Expression through Smad3 Signaling by NP Cells and its Role in Degenerative Disc Disease

Global Spine Journal, 2014
Introduction Objective To investigate TGFβ regulation of galectin-3 expression in nucleus pulposus (NP) cells and its role in degenerative disc disease.
Y. Tian, P. Cao, W. Yuan, J. Li, I. M Shapiro, M. Risbud   +5 more
doaj   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Galectin-3 Regulates Indoleamine-2,3-dioxygenase-Dependent Cross-Talk between Colon-Infiltrating Dendritic Cells and T Regulatory Cells and May Represent a Valuable Biomarker for Monitoring the Progression of Ulcerative Colitis

Cells, 2019
Galectin-3 regulates numerous biological processes in the gut. We investigated molecular mechanisms responsible for the Galectin-3-dependent regulation of colon inflammation and evaluated whether Galectin-3 may be used as biomarker for monitoring the ...
Vladislav Volarevic, Natasa Zdravkovic, Carl Randall Harrell, Nebojsa Arsenijevic, Crissy Fellabaum, Valentin Djonov, Miodrag L. Lukic, Bojana Simovic Markovic   +7 more
doaj   +1 more source

Duodenal intraepithelial lymphocytes of children with cow milk allergy preferentially bind the glycan-binding protein galectin-3 [PDF]

, 2009
A breakdown in intestinal homeostasis results in inflammatory bowel diseases including coeliac disease and allergy. Galectins, evolutionarily conserved beta-galactoside-binding proteins, can modulate immune-epithelial cell interactions by influencing ...
Ahmed, H., Cueto Rua, Eduardo, Docena, Guillermo H., Drut, Ricardo, Guzman, Luciana, Mercer, Natalia, Rabinovich, Gabriel Adrián, Toscano, Marta Alicia, Vasta, G. R.   +8 more
core   +3 more sources

Galectin-3 favours tumour metastasis via the activation of β-catenin signalling in hepatocellular carcinoma

British Journal of Cancer, 2020
Background High probability of metastasis limited the long-term survival of patients with hepatocellular carcinoma (HCC). Our previous study revealed that Galectin-3 was closely associated with poor prognosis in HCC patients.
Mengjia Song, Q. Pan, Jieying Yang, Junyi He, Jianxiong Zeng, Shao-Ang Cheng, Yue Huang, Ziqi Zhou, Qian Zhu, Chaopin Yang, Yulong Han, Yan Tang, Hao Chen, D. Weng, J. Xia   +14 more
semanticscholar   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]

, 2017
Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena, Carabias, Pablo, Troncoso, María Fernanda   +2 more
core   +1 more source