Results 11 to 20 of about 18,892,704 (362)

Macrophage‐derived galectin‐3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF‐κB/NLRP3 during atherosclerosis [PDF]

Clinical and Translational Medicine
Background Pyroptosis, apoptosis and necroptosis (PANoptosis) simultaneously occur and are extensively cross‐linked in infectious and inflammatory diseases.
Zihui Yuan, Haitao Li, Bing Xing Ruan, Hongyi Huang, Yiqing Li, Jian Wang   +5 more
doaj   +3 more sources

Galectin-3 in Cardiovascular Diseases

International Journal of Molecular Sciences, 2020
Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with pleiotropic regulatory activities and several physiological cellular functions, such as cellular growth, proliferation, apoptosis, differentiation, cellular ...
V. Blanda, U. Bracale, M. D. Di Taranto, G. Fortunato   +3 more
semanticscholar   +4 more sources

Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin [PDF]

Molecular Medicine
The galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral, Xiaoxin Li, Weikun Wang, Oluwatobi Adegbite, Yaoyu Pang, Thomas Gledhill, Sandra Sreenivas, Lu-Yun Lian, Lu-Gang Yu   +8 more
doaj   +2 more sources

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection.

PLoS Pathogens, 2020
Aspergillus fumigatus is an opportunistic mold that infects patients who are immunocompromised or have chronic lung disease, causing significant morbidity and mortality in these populations. While the factors governing the host response to A.
Brendan D Snarr, Guillaume St-Pierre, Benjamin Ralph, Mélanie Lehoux, Yukiko Sato, Ann Rancourt, Takahiro Takazono, Shane R Baistrocchi, Rachel Corsini, Matthew P Cheng, Michele Sugrue, Lindsey R Baden, Koichi Izumikawa, Hiroshi Mukae, John R Wingard, Irah L King, Maziar Divangahi, Masahiko S Satoh, Bryan G Yipp, Sachiko Sato, Donald C Sheppard   +20 more
doaj   +2 more sources

IL (Interleukin)-10–STAT3–Galectin-3 Axis Is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction

Circulation, 2018
Background: Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells and reparative fibrosis during wound healing. CD206+ macrophages are involved in tissue repair through phagocytosis and fibrosis after myocardial
K. Shirakawa, J. Endo, M. Kataoka, Yoshinori Katsumata, N. Yoshida, Tsunehisa Yamamoto, Sarasa Isobe, Hidenori Moriyama, S. Goto, Hiroki Kitakata, T. Hiraide, K. Fukuda, M. Sano   +12 more
semanticscholar   +3 more sources

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance [PDF]

Cell, 2016
Pingping Li, Shuainan Liu, Min Lü, Gautum K. Bandyopadhyay, Dayoung Oh, Takeshi Imamura, Andrew M. Johnson, Dorothy D. Sears, Zhufang Shen, Bing Cui, Lijuan Kong, Shaocong Hou, Xiao Liang, Salvatore Iovino, Steven M. Watkins, Wei Ying, Olivia Osborn, Joshua Wollam, Martin Brenner, Jerrold M. Olefsky   +19 more
openalex   +3 more sources

Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers [PDF]

, 2013
Background: Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx.
Argüeso, Pablo, Bertozzi, Carolyn R., Cao, Ziyhi, Godula, Kamil, Mantelli, Flavio, Mauris, Jerome, Panjwani, Noorjahan, Woodward, Ashley M.   +7 more
core   +15 more sources

Evaluation of galectins 1 and 3 expression in canine melanoma [PDF]

Pesquisa Veterinária Brasileira, 2021
: Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins.
Jéssica S. Garcia, Nicolle G.T.Q. Hazarbassanov, Júlia C. Nakamura, Victor Nowosh, Bruno Cogliati, Lilian Rose Marques de Sá, Cristina O. Massoco   +6 more
doaj   +1 more source

Targeting galectin-3 in inflammatory and fibrotic diseases.

TIPS - Trends in Pharmacological Sciences, 2023
Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections caused by COVID-19, and neuroinflammatory disorders.
Selena Bouffette, I. Botez, F. De Ceuninck   +2 more
semanticscholar   +1 more source

Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis.

Clinical Immunology, 2022
Galectin-3, an attractive molecule of innate immunity, has been reported to be involved in the neuroinflammatory diseases. However, the role of Galectin-3 in autoimmune uveitis is still unclear. The purpose of this study was to investigate the effect and
Yusen Liu, Chenyang Zhao, Jiayu Meng, Na Li, Zongren Xu, Xianyang Liu, Shengping Hou   +6 more
semanticscholar   +1 more source