Results 181 to 190 of about 51,657 (292)

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Galectins at the crossroads of tumor immunity, metabolism, and metastasis: mechanisms, therapeutic resistance, and translational opportunities. [PDF]

Front Immunol
Jin C, Wang W, Gao Y.
europepmc   +1 more source

Moringa oleifera Lam. Seed Lectin (WSMoL) Attenuates Parkinsonian Symptoms in Mice via Anti‐Inflammatory, Antioxidant, and Neurotransmitter‐Modulating Effects

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
WSMoL attenuates motor impairment, neuroinflammation, oxidative stress, and monoamine depletion in a rotenone‐induced model of Parkinson's disease. The involvement of D1 receptor‐mediated signaling is demonstrated, providing new insights into the mechanisms underlying its neuroprotective effects and supporting WSMoL as a promising candidate for further
Leydianne Leite de Siqueira Patriota, Emanuel Davi Lima de Matos Leão, Maria Nívea Bezerra da Silva, Amanda de Oliveira Marinho, Bárbara Raíssa Ferreira de Lima, Jainaldo Alves da Costa, Luciclaudio Cassimiro de Amorim, Valéria Bianca de Souza Santos, Patrícia Maria Guedes Paiva, Michelly Cristiny Pereira, Daniella Carla Napoleão, Jorge Vinícius Fernandes Lima Cavalcanti, Leucio Duarte Vieira, Michelle Melgarejo da Rosa, Thiago Henrique Napoleão   +14 more
wiley   +1 more source

The Effect of COVID-19 Vaccines on Chronic Inflammatory Remodeling in NSTEMI Patients: A Galectin-3-Based Single-Center Study. [PDF]

J Clin Med
Koksal A, Tomakin M, Saribaş MS, Akkaya F, Ustabas FC, Caltekin I, Altay DU, Noyan T, Aygun A.   +8 more
europepmc   +1 more source

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single‐cell and bulk transcriptomic analysis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative single‐cell and bulk transcriptomic analyses identified a highly inflammatory macrophage state and a vascular smooth muscle cell (VSMC) remodeling continuum in human atherosclerotic plaques. Candidate ligand‐receptor and ligand‐associated target gene expression patterns linked inflammatory macrophage activation with osteogenic/modulated ...
Xinyu Dong, Xuesong Hu, Qi Liu, Yuhao Dong, Yan Xuan, Muning Wang, Siyao Chang, Tianyi Lu, Zhiyang Han   +8 more
wiley   +1 more source

In Vitro Activity of Citrus IntegroPectin Against Breast Cancer and Colon Cancer

ChemFoodChem, Volume 2, Issue 3, September 2026.
Image shows microscopic photographs of MCF‐7 cells in the presence of lemon, red orange, and sweet orange IntegroPectin bioconjugates at 0.5 or 1.0 mg/mL concentration after 24 h next to a photograph of MCF‐7 cells as such (control). ABSTRACT We investigate the ability of IntegroPectin bioconjugates obtained via acoustic cavitation of lemon, red orange,
Claudia D'Anna, Caterina Di Sano, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna, Mario Pagliaro   +5 more
wiley   +1 more source

The C‐Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus

European Journal of Immunology, Volume 56, Issue 9, September 2026.
Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle‐dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages.
Vladimir Bokun, Wengang Chai, Robert Buchanan, Elliot Murphy, Yan Liu, Beth Holder, Alexiane Decout   +6 more
wiley   +1 more source

Identification and Studies of Highly Potent and Selective Heterobifunctional Galectin‑3 Degraders. [PDF]

ACS Med Chem Lett
Liu C, Wang W, Balog AJ, Traeger S, Panda M, Kalidindi N, Salinger A, Amako Y, Dongre AR, Locke G, Yu F, Newitt JA, Kiefer SE, Naglich J, Cheng D, Sale H, Ellsworth BA, Regueiro-Ren A.   +17 more
europepmc   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source