Results 181 to 190 of about 53,384 (285)

sox17 Mutagenesis Reveals Compounding Effects ofMaternal and Zygotic Contribution on Microglia Abundance

Glia, Volume 75, Issue 1, January 2027.
sox17 is a maternal effect gene impacting microglia and microglia precursor abundance. sox17 mRNA injection timed to maternal contribution rescues abundance. A CRISPR screen reveals f11r.1, gas6, and mpp1 also regulate microglia abundance. ABSTRACT Embryonic development is shaped by maternal and zygotic factors but how the interplay between these ...
Camden A. Spring, John Dennen, Dailin Gan, Jun Li, Cody J. Smith   +4 more
wiley   +1 more source

Higher Cardiorespiratory Fitness Is Associated With a Lower Burden of Metabolic Syndrome Traits: A Cross‐Sectional Analysis of 39 197 UK Adults

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11608-11620, December 2026.
ABSTRACT Aims To investigate associations of cardiorespiratory fitness (CRF) with metabolic syndrome (MetS) trait count, MetS prevalence and individual MetS traits in a large population‐based cohort. Materials and Methods This cross‐sectional study analysed data for 39 197 adults from a UK‐based independent healthcare charity (mean ± SD: age, 45.8 ± 9 ...
Scott A. Willis, Annalena Phillipp, Kevin Deighton, Christopher Goodwin, Daniel J. Cuthbertson, Shelley E. Keating, Christopher J. A. Pugh, Jonathan G. Stine, Gaël Ennequin, Alexis Couret, David J. Stensel, Guruprasad P. Aithal, Thomas Yates, James A. King   +13 more
wiley   +1 more source

Diagnostic Performance of Galectin-1 and Mucin-1 in Uterine Tumors: A Case-Control Study. [PDF]

Curr Issues Mol Biol
Karioti P, Sidera A, Tsakiridis I, Kourti A, Karavas G, Dagklis T, Mamopoulos A, Athanasiadis A, Makedou K, Kalogiannidis I.   +9 more
europepmc   +1 more source

Liver Injury Due to Hormonal Contraceptives in the Modern Era

Liver International, Volume 46, Issue 12, December 2026.
ABSTRACT Background and Aims Hormonal agents and their association with liver injury remain a concern in clinical practice. This study aimed to characterise the biochemical and clinical features of hormonal agent‐associated liver injury and compare them with a control group of age‐ and gender‐matched cases of liver injury caused by non‐hormonal drugs ...
Raj Vuppalanchi, A. Sidney Barritt, Anjali Rai, Huiman Barnhardt, Sherry Gu, Yi‐Ju Li, Naga Chalasani, for the Drug‐Induced Liver Injury Network, Naga Chalasani, Marwan Ghabril, Raj Vuppalanchi, Bob Fontana, Alisa Likhitsup, Vincent Chen, Victoria Shakhin, Paul Watkins, Sid Barritt, B. B. Behera, Jacquee Simpson, Herb Bonkovsky, Dee Faust, Andrew Stolz, Lily Dara, Neil Kaplowitz, Susan Milstein, Gina Choi, Jacqueline Nguyen, Angela Yeh, Dina Halegoua‐DeMarzio, Victor Navarro, Manish Thapar, Manisha Verma, Katrin Koy‐Pan, Verma Manisha, Cynthia Miller, Angela Pallotto, Christopher Koh, Beverly Niles, Jaha Norman, Huiman Barnhart, Matthew Baum, Jiezhun Gu, Yi‐Ju Li, Michelle McClanahan‐Crowder, Jeremy Mercer, Patricia Montana, Viviana Moreno, Eilene Pham, Hoss Rostami, Sheri Ussery, Kaye Williams, Stephanie Wu, Peter Hoffmann, Kidney Diseases, José Serrano, Jay Hoofnagle, Averell H. Sherker   +56 more
wiley   +1 more source

Glycosylation Encodes Selective Galectin Recognition and Signaling by Osteopontin. [PDF]

JACS Au
Bermejo IA, Balzo DD, Azkargorta M, Marina A, Delgado S, Gimeno A, Peccati F, Diercks T, Elortza F, Millet O, Ardá A, Mateos B, Jiménez-Barbero J, Unione L.   +13 more
europepmc   +1 more source

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

Synergistic Regulation of Tumor Immunity by Integrins and Lectins: From Molecular Mechanisms to Dual-Targeted Therapy. [PDF]

Int J Mol Sci
Liu R, Liu C, Guo X, Li P, Niu Y, Zhao J, Zhang J, Su X, Chen J, Jin J, Yang J.   +10 more
europepmc   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Serum Glial-Related Biomarkers Show Distinct Contributions to Radiologic and Clinical Outcomes in Early Multiple Sclerosis. [PDF]

Neurol Neuroimmunol Neuroinflamm
Comabella M, Bollo L, Fissolo N, Benkert P, Klass I, Tur C, Saez de Gordoa E, Gutierrez L, Auger C, Rio J, Sastre-Garriga J, Tintore M, Kuhle J, Rovira À, Montalban X.   +14 more
europepmc   +1 more source

Push–pull hypothesis of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract The “push–pull” hypothesis of Alzheimer's disease (AD) emerges from a careful examination of the key discoveries over the past 40 years. Specifically, amyloid beta (Aβ) plays a direct role impairing endolysosome activity in neurons and microglia, promoting the collapse of proteostasis, reducing tau degradation, and facilitating the cell‐to ...
Matthew Townsend
wiley   +1 more source