Selected Blood-Accessible Biomarkers in Prostate Cancer Radiotherapy: A PRISMA-ScR Timing-Window Framework Beyond PSA. [PDF]
Grujić M +12 more
europepmc +1 more source
High‐Content CRISPR Screening: Methods and Applications
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang +6 more
wiley +1 more source
Galectin-3 Beyond Conventional Cardiac Biomarkers and Its Incremental Prognostic Value in Heart Failure: A Systematic Review. [PDF]
Hemdev V +5 more
europepmc +1 more source
Tissue‐Resident Macrophage in Inflammation and Cancer
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang +13 more
wiley +1 more source
Galectin-3-A Multifunctional Molecule and a Key Player in Health and Disease. [PDF]
Lupu Surlea A +7 more
europepmc +1 more source
Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie +7 more
wiley +1 more source
Association between galectin-3 and echocardiographic changes in hospitalized patients with coronavirus disease 2019: A retrospective observational study. [PDF]
Egiashvili N +4 more
europepmc +1 more source
Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony
ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung +4 more
wiley +1 more source
Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons. [PDF]
Smith EM, Chanaday NL, Maday S.
europepmc +1 more source
Human galectin-1 triggers apoptosis via ceramide mediated mitochondrial pathway [PDF]
Ion Gabriella
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