Results 81 to 90 of about 53,384 (285)

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe   +8 more
wiley   +1 more source

The galectin lattice at a glance [PDF]

open access: yesJournal of Cell Science, 2015
ABSTRACTGalectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The 15 mammalian galectins have either one or two conserved carbohydrate recognition domains (CRDs), with galectin-3 being able to pentamerize; they form complexes that crosslink glycosylated ligands to form a dynamic lattice.
Ivan R, Nabi   +2 more
openaire   +2 more sources

Shiga Toxin—A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

open access: yesToxins, 2017
The cellular entry of the bacterial Shiga toxin and the related verotoxins has been scrutinized in quite some detail. This is due to their importance as a threat to human health.
Ludger Johannes
doaj   +1 more source

The content of hypoxia-inducible factors and mediators of immunosuppression in the blood in diseases associated with hypoxia

open access: yesБюллетень сибирской медицины, 2020
The aim of the study was to identify general patterns and features of changes in the content of hypoxia-inducible factors-1 and -2 in association with an imbalance of cytokines (IL-10, IL-13, galectin-2 and -9, IFN-gamma) in the blood in diseases ...
S. P. Chumakova   +8 more
doaj   +1 more source

Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

open access: yesAnimal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen   +7 more
wiley   +1 more source

Galectins in epithelial functions [PDF]

open access: yesTissue Barriers, 2014
Galectins are a family of animal lectins comprising 15 members in vertebrates. These proteins are involved in many biological processes including epithelial homeostasis and tumor progression by displaying intracellular and extracellular activities. Hence Galectins can be found either in the cytoplasm or the nucleus, associated with membranes or in the ...
Viguier, Mireille   +4 more
openaire   +3 more sources

Galectin-3, galectin-9, and interleukin- 18, monocyte activation and turnover and simian immunodeficiency virus-associated 2 cardiac pathology or encephalitis: A narrative review

open access: yesIndian Journal of Allergy Asthma and Immunology
In the context of simian immunodeficiency virus (SIV) infection, this editorial commentary minireview addresses the roles of galectin-3, galectin-9, and interleukin-18 in monocyte activation and turnover.
Hinpetch Daungsupawong, Viroj Wiwanitkit
doaj   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

open access: yesArthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani   +17 more
wiley   +1 more source

Low translocon associated YopD-ALFA/YopD fluorescence signals in GFP-galectin-3 positive compartments.

open access: yes, 2022
(A) NbALFA staining of translocon associated YopD-ALFA in fixed cells. HeLa cells expressing myc-Rac1Q61L and GFP-galectin-3 were infected with WA-314-YopD-ALFA at an MOI of 50 for 50 min.
Maren Rudolph (11726318)   +4 more
core   +1 more source

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