Results 71 to 80 of about 51,657 (292)

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Galectins and cutaneous immunity

Dermatologica Sinica, 2012
Galectins are highly expressed in epithelial cells and immune cells. In skin, they can be detected in keratinocytes, melanocytes, dendritic cells, macrophages, and T cells. Galectins are present outside and inside the cells and thus may exhibit different
Huan-Yuan Chen, Chia-Hui Lo, Chi-Shan Li, Daniel K. Hsu, Fu-Tong Liu   +4 more
doaj   +1 more source

Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice [PDF]

, 2013
PMCID: PMC3579848This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Karla J. Castellanos (7918193), Perretti, M, Akasheh, RT, Mauro Perretti (241694), Rand T Akasheh, Jingbo Pang, Jingbo Pang (381396), Pini, M, Castellanos Karla J., Dianne Cooper, Davina H Rhodes, Mauro Perretti, Rhodes Davina H., Giamila Fantuzzi (315958), Fantuzzi, G, Fantuzzi Giamila, Cabay Robert J., Davina H. Rhodes (315954), Rand T. Akasheh (7918190), Cooper Dianne, Cabay, RJ, Pang Jingbo, Robert J. Cabay (7918196), Maria Pini (315953), Robert J Cabay, Pini Maria, Castellanos, KJ, Karla J Castellanos, Rhodes, DH, Maria Pini, Akasheh Rand T., Dianne Cooper (381398), Cooper, D, Giamila Fantuzzi, Pang, J, Perretti Mauro   +35 more
core   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Targeting intracellular galectins for cancer treatment

Frontiers in Immunology, 2023
Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their ...
Rita Nehmé, Yves St-Pierre
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function

Frontiers in Immunology, 2019
Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense.
Brian S. Robinson, Connie M. Arthur, Birk Evavold, Ethan Roback, Nourine A. Kamili, Caleb S. Stowell, Mary L. Vallecillo-Zúniga, Pam M. Van Ry, Marcelo Dias-Baruffi, Richard D. Cummings, Sean R. Stowell   +10 more
doaj   +1 more source

Galectin-3 plasma levels are associated with left atrial contractile function in long-distance runners. [PDF]

Exp Physiol
Abstract High‐intensity endurance exercise induces myocardial remodelling as an adaptive response to sustained volume overload, but excessive cumulative training might also favour deleterious cardiac remodelling, including atrial fibrosis. Whether acute marathon running engages circulating fibrosis‐related biomarkers and whether these biomarkers track ...
Contreras-Briceño F, Sanhueza-Olivares F, Fernández R, Llevaneras S, Castro PF, Gabrielli L, Chiong M.   +6 more
europepmc   +2 more sources

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Microglial Lectins in Health and Neurological Diseases

Frontiers in Molecular Neuroscience, 2018
Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the influence of the local environment and cell-cell interaction, microglia exhibit a multidimensional and
Jian Jing Siew, Jian Jing Siew, Yijuang Chern, Yijuang Chern   +3 more
doaj   +1 more source