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Galectin-3 and cancer (Review).
International Journal of Oncology, 2004Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported.
Califice, Stéphane +2 more
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Extracellular functions of galectin-3
Glycoconjugate Journal, 2002Galectin-3 has been suspected of modulating cell to extracellular matrix interactions in a novel fashion ever since it was first described. However, the rapid accumulation of research data in just the last 8 years alone has completely changed our perspective of this multifunctional protein.
Josiah, Ochieng +2 more
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Cardiovascular Drugs and Therapy, 2014
Myocardial galectin-3 is upregulated upon cardiac stressors such as angiotensin II and pressure overload leading to cardiac remodeling and heart failure. The expression level of galectin-3 mirrors the progression and severity of heart failure and therefore, galectin-3 is being used as a biomarker for heart failure.
de Boer, Rudolf A. +7 more
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Myocardial galectin-3 is upregulated upon cardiac stressors such as angiotensin II and pressure overload leading to cardiac remodeling and heart failure. The expression level of galectin-3 mirrors the progression and severity of heart failure and therefore, galectin-3 is being used as a biomarker for heart failure.
de Boer, Rudolf A. +7 more
openaire +1 more source
Nucleocytoplasmic Shuttling of Galectin-3
2014A large number of observations on the nuclear versus cytoplasmic distribution of galectin-3 have been reported, correlating the presence or absence of the protein in a particular compartment of the cell to various parameters such as source of the cells under study, specific cell type, culture conditions, proliferation status of the cell/culture, or ...
Eric J, Arnoys +2 more
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Endogenous galectin-3 expression levels modulate immune responses in galectin-3 transgenic mice
Molecular Immunology, 2015Galectin-3 (Gal-3), a β-galactoside-binding mammalian lectin, is involved in cancer progression and metastasis. However, there is an unmet need to identify the underlying mechanisms of cancer metastasis mediated by endogenous host galectin-3. Galectin-3 is also known to be an important regulator of immune responses.
Aparna D. Chaudhari +3 more
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Carbohydrate Polymers, 2019
Pancreatic ductal adenocarcinoma is a highly malignant gastrointestinal tumor. Molecular targeting therapy for pancreatic cancer is still limited.
Yanli Yao +7 more
semanticscholar +1 more source
Pancreatic ductal adenocarcinoma is a highly malignant gastrointestinal tumor. Molecular targeting therapy for pancreatic cancer is still limited.
Yanli Yao +7 more
semanticscholar +1 more source
Targeting galectin-driven regulatory circuits in cancer and fibrosis
Nature Reviews Drug Discovery, 2023Karina V Mariño +2 more
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