Results 81 to 90 of about 13,626 (296)

Duodenal intraepithelial lymphocytes of children with cow milk allergy preferentially bind the glycan-binding protein galectin-3 [PDF]

, 2009
A breakdown in intestinal homeostasis results in inflammatory bowel diseases including coeliac disease and allergy. Galectins, evolutionarily conserved beta-galactoside-binding proteins, can modulate immune-epithelial cell interactions by influencing ...
Ahmed, H., Cueto Rua, Eduardo, Docena, Guillermo H., Drut, Ricardo, Guzman, Luciana, Mercer, Natalia, Rabinovich, Gabriel Adrián, Toscano, Marta Alicia, Vasta, G. R.   +8 more
core   +3 more sources

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

The Ciona intestinalis immune-related galectin genes (CiLgals-a and CiLgals-b) are expressed by the gastric epithelium [PDF]

, 2017
The transcription of two Ciona intestinalis galectin genes (CiLgals-a and CiLgalseb) is uparegulated by LPS in the pharynxis (hemocytes, vessel epithelium, endostilar zones) which is retained the main organ of the immunity.
Cammarata M, Parrinello D, Parrinello N, Sanfratello Maria Antonietta, Testasecca Lelia, Vizzini A   +5 more
core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Targeting Galectins With Glycomimetics

Frontiers in Chemistry, 2020
Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation.
Sara Bertuzzi, Jon I. Quintana, Ana Ardá, Ana Gimeno, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero   +6 more
doaj   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, EarlyView.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source

Revisiting Multi-Omics Data to Unravel Galectins as Prognostic Factors in Head and Neck Squamous Cell Carcinoma

Biomedicines
Head and Neck Squamous Cell Carcinoma (HNSCC) is a malignant cancer with a poor prognosis. Galectins (Gal) have been the subject of intensive research, but the comparative prognostic value of each Gal type is not yet understood.
Oriana Barros, Vito Giuseppe D’Agostino, Lucio Santos, Rita Ferreira, Rui Vitorino   +4 more
doaj   +1 more source

Regulation of Eosinophil Recruitment and Activation by Galectins in Allergic Asthma

Frontiers in Medicine, 2017
Eosinophils are differentiated granulocytes that are recruited from the bone marrow to sites of inflammation via the vascular system. Allergic asthma is characterized by the presence of large numbers of eosinophils in the lungs and airways.
Savita P. Rao, Xiao Na Ge, P. Sriramarao
doaj   +1 more source

Synthesis of carbohydrate capped silicon nanoparticles and their reduced cytotoxicity, in vivo toxicity, and cellular uptake [PDF]

, 2015
The development of smart targeted nanoparticles (NPs) that can identify and deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. Obtaining knowledge
Ahire, Ahire, Barthel, Buford, Chandrasekaran, Chen, Dai, Danishefsky, Deguchi, dos Santos, Dwek, Erogbogbo, Fako, Foucaud, Fricker, Gerber, Giannaccini, Gliga, Hakomori, Hakomori, Harding, Hu, Jenei, Johannessen, Kayser, Kayser, Kim, Kim, Kirchner, Lee, Lerchen, Lidsky, Lingwood, Liu, Macher, Mahmoudi, Marcon, Mayne, Mercer, Moghimi, Moore, Moros, Murdock, Nangia-Makker, Nazarian, Nieuwkoop, Nilsson, O'Farrell, Pascual, Pastan, Petitou, Pieters, Rabinovich, Raman, Rojo, Rye, Sager, Schrag, Seeberger, Seker, Sherwood, Silverstein, Simanek, Sofer, Straussman, Su, Tjelle, Tseng, Vankuppeveld, Varki, Villanueva, Wang, Wang, Werz, Wick, Willingham, Wilson   +76 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source