Results 11 to 20 of about 92,008 (245)

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

open access: yesCancer Cell International, 2022
Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai   +6 more
doaj   +1 more source

A-Kinase Anchor Protein 95 Is Involved in ERK1/2–Elk-1 Signal Transduction in Colon Cancer

open access: yesAnalytical Cellular Pathology, 2023
Objectives. To assess A-kinase anchor protein 95 (AKAP95), B-Raf, extracellular regulated protein kinases 1/2 (ERK1/2), and Elk-1 expression in colon cancer tissue, and characterize AKAP95 associations with B-Raf, ERK1/2, Elk-1, and colon cancer ...
Xiangyu Kong   +5 more
doaj   +1 more source

IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization

open access: yesTranslational Oncology, 2023
Introduction: N6-methyladenosine (m6A) is an emerging epigenetic modification, which plays a crucial role in the development of cancer. Nevertheless, the underlying mechanism of m6A-associated proteins and m6A modification in gallbladder cancer remains ...
Jian Qin   +7 more
doaj   +1 more source

Gallbladder Volvulus [PDF]

open access: yesHPB Surgery, 1992
A case of torsion of the gallbladder is presented. This is a rare condition that occurs more frequently in elderly females, it is associated with anatomical variants related to abnormal fixation of the gallbladder to the liver bed. It is usually diagnosed at laparotomy and treatment consists of cholecystectomy.
Gonzalez-Fisher, Ricardo F.   +3 more
openaire   +2 more sources

Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

open access: yesNature Communications, 2022
Metabolic conditions associated with alterations of the gut microbiome, such as obesity and diabetes, predispose to gallstone disease. Here the authors demonstrate that the gut microbiome, in particular the genus Desulfovibrionale, contribute to ...
Hai Hu   +14 more
doaj   +1 more source

Laparoscopic or open liver resection for intrahepatic cholangiocarcinoma: A meta-analysis and systematic review

open access: yesFrontiers in Oncology, 2023
BackgroundAlthough laparoscopic hepatectomy has been widely used in the treatment of benign and malignant liver diseases, its applicability in intrahepatic cholangiocarcinoma (ICC) is controversial.
Xin Zhao   +16 more
doaj   +1 more source

Effect of LncRNA GHET1 on Proliferation, Apoptosis, and Metastasis of Gallbladder Cancer Cells by Targeting miR-27b

open access: yesZhongliu Fangzhi Yanjiu, 2023
Objective To investigate the effect of GHET1 on the biological behavior of gallbladder cancer cells and the regulatory mechanism of GHET1 on miR-27b. Methods The expression of GHET1 and miR-27b in 50 samples of gallbladder cancer was detected by real ...
YANG Zhen, LI Wenchuan, ZHOU Ning
doaj   +1 more source

Gallbladder carcinosarcoma [PDF]

open access: yesBMJ Case Reports, 2011
Gallbladder carcinosarcoma is a rare gastrointestinal tract malignant tumour, which contains both epithelial cancer component and mesenchymal sarcoma component. Because of its unique anatomic location and unspecific medical presentation, preoperative diagnosis is difficult. The prognosis of gallbladder carcinoma is poor with median survival time of 5.5
Jeffrey J, Pu, Weize, Wu
openaire   +2 more sources

The Value of Deep Learning in Gallbladder Lesion Characterization

open access: yesDiagnostics, 2023
Background: The similarity of gallbladder cancer and benign gallbladder lesions brings challenges to diagnosing gallbladder cancer (GBC). This study investigated whether a convolutional neural network (CNN) could adequately differentiate GBC from benign ...
Yunchao Yin   +5 more
doaj   +1 more source

Gallbladder Agenesis [PDF]

open access: yesCase Reports in Gastroenterology, 2011
Gallbladder agenesis is a rare entity with an estimated incidence of 10-65 per 100,000. Females are more commonly affected (ratio 3:1), typically presenting in the 2nd or 3rd decade of life. Despite an absent gallbladder, half of patients present with symptoms similar to biliary colic, which is poorly understood.
Pashtoon Murtaza Kasi   +4 more
openaire   +3 more sources

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