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PET Imaging Using Gallium-68 (68Ga) RM2
PET Clinics, 2022Molecular imaging is advancing rapidly with promising new molecular targets emerging for theragnostic, ie, imaging and treatment with the same compound, to provide targeted, personalized medicine. Gastrin-releasing peptide receptors (GRPR) are overexpressed in prostate cancer.
Heying Duan, Andrei Iagaru
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Current Radiopharmaceuticals, 2016
Over the past several years, Positron Emission Tomography (PET) imaging agents labeled with ;68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is conveniently produced from a germanium-68/gallium-68 (68Ge/68Ga) generator.
Lucia, Martiniova +3 more
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Over the past several years, Positron Emission Tomography (PET) imaging agents labeled with ;68Gallium (68Ga) have undergone a significant increase in clinical utilization. 68Ga is conveniently produced from a germanium-68/gallium-68 (68Ge/68Ga) generator.
Lucia, Martiniova +3 more
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Nuclear Medicine Communications, 2013
The increased availability of PET facilities worldwide has sparked renewed interest in the use of generator-produced tracers such as gallium-68 (Ga). Imaging with Ga provides exciting opportunities in terms of new ligand-labelling possibilities and the exploration of novel clinical applications.
Mariza, Vorster +3 more
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The increased availability of PET facilities worldwide has sparked renewed interest in the use of generator-produced tracers such as gallium-68 (Ga). Imaging with Ga provides exciting opportunities in terms of new ligand-labelling possibilities and the exploration of novel clinical applications.
Mariza, Vorster +3 more
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The International Journal of Applied Radiation and Isotopes, 1961
The generator and method for milking (cow) 68-min gallium-68 from its 290-day germanium-68 parent are described. The generator consists of a glass column 25 mm in diameter containing 10 g of chromatographic alumina held on a course fritted glass disc and retained at the top by a piece of filter clotid and a polyethylene split washer.
M.W. Greene, W.D. Tucker
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The generator and method for milking (cow) 68-min gallium-68 from its 290-day germanium-68 parent are described. The generator consists of a glass column 25 mm in diameter containing 10 g of chromatographic alumina held on a course fritted glass disc and retained at the top by a piece of filter clotid and a polyethylene split washer.
M.W. Greene, W.D. Tucker
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Gallium-68 Prostate-Specific Membrane Antigen PET Imaging
PET Clinics, 2017The role of gallium-68 (68Ga) prostate-specific membrane antigen (PSMA) PET imaging is evolving and finding its place in the imaging armamentarium for prostate cancer (PCa). Despite the progress of conventional imaging strategies, significant limitations remain, including identification of small-volume disease and assessment of bone.
Michael S, Hofman, Amir, Iravani
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Gallium-68 Labelled Radiopharmaceuticals for Imaging Inflammatory Disorders
Seminars in Nuclear Medicine, 2023Inflammation is an important component of several chronic and debilitating diseases that result in significant morbidity and mortality. This is best evidenced within the cardiovascular system where it may manifest as atherosclerosis or myocarditis, and at the extreme end of the spectrum as myocardial infarction, ventricular remodeling, or cardiac ...
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Bifunctional Gallium-68 Chelators: Past, Present, and Future
Seminars in Nuclear Medicine, 2016This article reviews the development of bifunctional chelates for synthesising (68)Ga radiopharmaceuticals. It structures the chelates into groups of macrocycles, nonmacrocycles, and chimeric derivatives. The most relevant bifunctional chelates are discussed in chelate structure, parameters of (68)Ga-labeling, and stability of the (68)Ga-chelate ...
Philipp, Spang +2 more
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Gallium‐68
SummaryGallium‐68 (Ga‐68) labelled prostate‐specific membrane antigen (PSMA) imaging by positron emission tomography (PET) has emerged as a promising tool for staging of prostate cancer and restaging of disease in recurrence or biochemical failure after definitive treatment of prostate cancer. Ga‐68 PSMA PET produces high target‐to‐background images of
Law, W Phillip +3 more
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Gallium-68 EDTA PET/CT for Renal Imaging
Seminars in Nuclear Medicine, 2016Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration and have been radiolabelled with a ...
Michael S, Hofman, Rodney J, Hicks
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GALLIUM-68 LABELING OF ALBU MIN AND ALBUMIN MICROSPHERES
Journal of Computer Assisted Tomography, 1979Because of the high stability constant of gallium transferrin, the formation of a protein that will be stable in vivo and labeled with gallium-68 (a positron emitter) requires preliminary coupling of a strong chelating group to the protein. In the present study, we have used a reaction developed by Krejcarek and Tucker, in which DTPA is coupled to ...
S J, Wagner, M J, Welch
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