Results 151 to 160 of about 53,961 (251)

An Evaluation of the Accuracy of Point of Care Ultrasound by Family Physicians in Rural British Columbia, Canada: Methodological Insights

Australian Journal of Rural Health, Volume 34, Issue 2, April 2026.
ABSTRACT Objective This study investigated the diagnostic accuracy of point of care ultrasound (PoCUS) by rural family physicians (FPs), using consensus ‘imaging expert’ interpretation as the reference standard. Design Cross‐sectional. Setting British Columbia, Canada.
Anshu Parajulee, Oron Frenkel, Virginia Robinson, Patti Janssen, Jude Kornelsen   +4 more
wiley   +1 more source

Phenotype, Management, and Outcomes in Paediatric Acute Pancreatitis: A Real‐Life Cross‐Sectional Study

Acta Paediatrica, Volume 115, Issue 4, Page 951-958, April 2026.
ABSTRACT Aim Limited Canadian data on paediatric acute pancreatitis exist. A meta‐analysis of 48 studies reported equal prevalence of acute pancreatitis among various aetiologies, with rates of severe acute pancreatitis at 13.7% in North America.
Catherine Korman, Doha Elhaoua, Sarah Blain, Thomas Li, Mariam Mohamed, Alessandro David, Colette Deslandres, Ugur Halac, Martha Dirks, Kelly Grzywacz, Michel Lallier, Fernando Alvarez, Prévost Jantchou   +12 more
wiley   +1 more source

Circulating angiogenesis‐related biomarkers in sickle cell retinopathy and maculopathy

British Journal of Haematology, Volume 208, Issue 4, Page 1398-1406, April 2026.
Summary Sickle cell disease (SCD), encompassing genotypes such as HbSS and HbSC, leads to retinal complications such as sickle cell retinopathy (SCR) and maculopathy (SCM) through poorly understood mechanisms. This study explored associations of a panel of circulating angiogenesis‐related factors with SCR and SCM.
Rajani P. Brandsen, Ingeborg Klaassen, Renée de Caluwe, Erfan Nur, Bart J. Biemond, Roselie M. H. Diederen, Reinier O. Schlingemann   +6 more
wiley   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, Volume 183, Issue 8, Page 1653-1662, April 2026.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

The U-shaped association between the metabolic score for insulin resistance and incident gallstone disease: a population-based cohort study. [PDF]

Front Endocrinol (Lausanne)
Ming Y, He Y, Deng J, Xu F, Chen H, Zhu Y, Jiang J, Liu Y, Leng S.   +8 more
europepmc   +1 more source

Risk of acute pancreatitis with DPP‐4 inhibitors versus SGLT2 inhibitors in medication‐naïve individuals with diabetes: A target trial emulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3033-3043, April 2026.
Abstract Aims We investigated whether dipeptidyl peptidase‐4 inhibitor (DPP‐4i) use was associated with a higher risk of acute pancreatitis compared with sodium–glucose cotransporter 2 inhibitor (SGLT2i) use in antidiabetic medication‐naïve individuals.
Takashi Tatewaki, Akira Okada, Yuya Kimura, Hideo Yasunaga   +3 more
wiley   +1 more source

Endoscopic management of gallstone large bowel obstruction at a sigmoid diverticular stricture secondary to cholecystoduodenal fistula. [PDF]

J Surg Case Rep
Feng LR, Peter LG, Barrett CD, Matos MA, Henry R.   +4 more
europepmc   +1 more source

Sutimlimab in Patients With Cold Agglutinin Disease (CAD): Results From a Managed Access Program

European Journal of Haematology, Volume 116, Issue 4, Page 409-415, April 2026.
ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Sandra Maria Frey, Pauline Halberstadt, Ferras Alashkar, Veronika Lenz, H. Christian Reinhardt, Alexander Röth   +5 more
wiley   +1 more source

Bouveret's syndrome complicated by iatrogenic esophageal perforation after endoscopic gallstone retrieval: a case report. [PDF]

J Surg Case Rep
Korte JC, Klingelhöfer L, Nottberg V, Bardenhagen J, Mercanoglu B, Schraps N, Hackert T, Melling N.   +7 more
europepmc   +1 more source