Results 1 to 10 of about 32,729 (195)

Luteolin prevents cholesterol gallstone formation in mice by downregulating NRF2-mediated NPC1L1 expression

Food Science and Human Wellness
Luteolin, a flavonoid that has been developed for commercial use in health supplements and cosmetics, has the potential to treat hypercholesterolemia. Gallstone disease is a common disease worldwide.
Qihan Wang, Weiyi Shen, Wentao Shao, Zhaoyan Jiang, Gang Zhao, Hai Hu   +5 more
doaj   +1 more source

Alteration of gut microbiota in association with cholesterol gallstone formation in mice

BMC Gastroenterology, 2017
Background The gut microbiome exerts extensive roles in metabolism of nutrients, pharmaceuticals, organic chemicals. Little has been known for the role of gut microbiota in regulating cholesterol and bile acids in association with gallstone formation ...
Qihan Wang, Long Jiao, Chuanqi He, Haidong Sun, Qu Cai, Tianquan Han, Hai Hu   +6 more
doaj   +1 more source

Analysis of influencing factors of placement of pancreatic duct stent on recurrence of extrahepatic bile duct stones after ERCP lithotomy combined with ERBD [PDF]

Waike lilun yu shijian
Objective To investigate the impact of pancreatic duct stent on long-term recurrence of extrahepatic bile duct stones after endoscopic retrograde cholangiopancreatography (ERCP) lithotomy combined with endoscopic retrograde biliary drainage (ERBD), and ...
WANG Yubin, ZHANG Honglei, ZHANG Cheng, KONG Xiangyu, XIANG Yukai, YANG Yulong
doaj   +1 more source

The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients. [PDF]

PLoS ONE, 2016
Niemann Pick Type C1 Like 1 (NPC1L1) protein plays a key role in intestinal and hepatic cholesterol metabolism in humans. Genetic variation in NPC1L1 has been widely studied in recent years.
Jian Wu, Wei Cui, Qu Cai, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han, Hai Hu, Zhao-Yan Jiang   +7 more
doaj   +1 more source

Prevalence and risk factors of gallstone disease in Korean patients with ulcerative colitis [PDF]

Intestinal Research
Background/Aims The prevalence of gallstone disease in patients with ulcerative colitis (UC) is higher than in the general population. However, risk factors of gallstone disease in these patients remain unclear.
Kwangwoo Nam, Jae Yong Lee, Sang Hyoung Park, Ha Won Hwang, Ho-Su Lee, Kyunghwan Oh, Hee Seung Hong, Kyuwon Kim, Jin Hwa Park, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang   +15 more
doaj   +1 more source

Insight into the mechanism of gallstone disease by proteomic and metaproteomic characterization of human bile

Frontiers in Microbiology, 2023
IntroductionCholesterol gallstone disease is a prevalent condition that has a significant economic impact. However, the role of the bile microbiome in its development and the host’s responses to it remain poorly understood.MethodsIn this study, we ...
Xue-Ting Yang, Jie Wang, Ying-Hua Jiang, Lei Zhang, Ling Du, Jun Li, Feng Liu   +6 more
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Danning tablet alleviates cholecystitis caused by gallstone through enhancing bile secretion and rinsing

Pakistan Journal of Pharmaceutical Sciences
Danning tablets are widely used as a conservative treatment for gallstones in China. However, the underlying pharmacological mechanisms remain to be elucidated. We performed network pharmacology analyses.
Weiyi Shen, Fan Ding, Hongchao Zhang, Yixing Wang, Run Guo, Qihan Wang, Zhengyu Cui, Yan Shen, Lang Liu, Gang Zhao   +9 more
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Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study

npj Genomic Medicine, 2021
We conducted a Mendelian randomization study to determine the potential causal associations of gallstone disease, diabetes, serum calcium, triglyceride levels, smoking and alcohol consumption with acute and chronic pancreatitis.
Shuai Yuan, Edward L. Giovannucci, Susanna C. Larsson   +2 more
doaj   +1 more source

An unusual case of mechanical bowel obstruction due to cholecysto-intestinal fistula and impacted gallstone: A case report and literature review

SAGE Open Medical Case Reports, 2023
Gallstone ileus is a rare entity and constitutes an uncommon complication of gallstone disease. It is caused by the impaction of a gallstone in the gastrointestinal tract and may cause serious symptoms or even life-threatening complications. It should be
Ioannis G Gkionis, Theofanis G Kokkinakis, Andreas F Strehle, Mathaios E Flamourakis, Michail I Giakoumakis, Marios A Mannaris, Eleni I Kaloeidi, Eirini S Apostolaki, Manousos S Christodoulakis, Aggelos Laliotis   +9 more
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Identification of changes in bile composition in pancreaticobiliary reflux based on liquid chromatography/mass spectrometry metabolomics

BMC Gastroenterology
Introduction Pancreaticobiliary reflux (PBR) can induce gallstone formation; however, its pathogenic mechanism remains unclear. In this study, we explored the mechanism of PBR by the non-targeted metabolomic analysis of bile in patients with PBR ...
Xuanbo Da, Yukai Xiang, Hai Hu, Xiangyu Kong, Chen Qiu, Zhaoyan Jiang, Gang Zhao, Jingli Cai, Anhua Huang, Cheng Zhang, Chuanqi He, Beining Lv, Honglei Zhang, Yulong Yang   +13 more
doaj   +1 more source