Results 21 to 30 of about 33,356 (238)

Association between statin use and risk of gallstone disease and cholecystectomy: a meta-analysis of 590,086 patients [PDF]

open access: yesPeerJ, 2023
Background Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified.
Yu Chang   +4 more
doaj   +2 more sources

Gallstone disease [PDF]

open access: yesJournal of Internal Medicine, 2007
Abstract.Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk. Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing ...
H-U, Marschall, C, Einarsson
openaire   +2 more sources

IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization

open access: yesTranslational Oncology, 2023
Introduction: N6-methyladenosine (m6A) is an emerging epigenetic modification, which plays a crucial role in the development of cancer. Nevertheless, the underlying mechanism of m6A-associated proteins and m6A modification in gallbladder cancer remains ...
Jian Qin   +7 more
doaj   +1 more source

The Treatment of Gallstone Disease [PDF]

open access: yesDeutsches Ärzteblatt international, 2020
Gallstone disease affects up to 20% of the European population, and cholelithiasis is the most common reason for hospitalization in gastroenterology.This review is based on pertinent publications retrieved by a selective search of the literature, including the German clinical practice guidelines on the diagnosis and treatment of gallstones and ...
Carsten, Gutt   +2 more
openaire   +2 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

open access: yesHepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo   +14 more
wiley   +1 more source

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

open access: yesCancer Cell International, 2022
Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai   +6 more
doaj   +1 more source

Free fatty acids and triglyceride change in the gallbladder bile of gallstone patients with pancreaticobiliary reflux

open access: yesLipids in Health and Disease, 2021
Background Pancreaticobiliary reflux (PBR) causes chronic inflammation of the gallbladder mucosa and changes in the bile components, which are known to promote gallstone formation.
Yukai Xiang   +8 more
doaj   +1 more source

Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

open access: yesNature Communications, 2022
Metabolic conditions associated with alterations of the gut microbiome, such as obesity and diabetes, predispose to gallstone disease. Here the authors demonstrate that the gut microbiome, in particular the genus Desulfovibrionale, contribute to ...
Hai Hu   +14 more
doaj   +1 more source

Single Cell RNA-Sequencing Reveals a Murine Gallbladder Cell Transcriptome Atlas During the Process of Cholesterol Gallstone Formation

open access: yesFrontiers in Cell and Developmental Biology, 2021
Gallstone disease is a worldwide common disease. However, the knowledge concerning the gallbladder in the pathogenesis of cholesterol gallstone formation remains limited.
Jingjia Liang   +8 more
doaj   +1 more source

Estrogen: risk factor for Xinjiang female patients with gallstone [PDF]

open access: yesWaike lilun yu shijian, 2021
Objective To investigate estrogen as one of risk factors in women with gallstone in Xinjiang. Methods Estradiol, luteinizing hormone(LH), follicle-stimulating hormone(FSH), testosterone, progesterone, and prolactin in 204 women with gallstone were ...
Azatijiang Ainiwaer, Abuduwaili Aierken, YU Sufu, YU Wenqing, Kelimu
doaj   +1 more source

Home - About - Disclaimer - Privacy