Results 81 to 90 of about 4,877,486 (248)

Defining Age to Screen and Real‐World Effectiveness for Early‐Onset Colorectal Cancer

Cancer Science, EarlyView.
Implementation of a RAP‐based risk‐adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50–54‐year age group.
Le Wang, Yu Qiu, Xuechen Chen, Weimiao Wu, Chen Zhu, Weiwei Chen, Tingting Pan, Dong Hang, Lingbin Du   +8 more
wiley   +1 more source

Determinants for symptomatic gallstone disease readmissions – results from a cohort with screen-detected gallstone disease

, 2019
Aim of the study: Selection of patients for cholecystectomy is hampered by lack of objective criteria. The objectives of this cohort study were to identify if patient, symptoms, or gallstone disease characteristics determined readmission in an unselected
Shabanzadeh, D M, Shabanzadeh, D. M., Jørgensen, T, Jørgensen, T., Sørensen, L. T., Sørensen, L T   +5 more
core   +1 more source

Genetic Spectrum of Cholestasis in Tunisia and Diagnostic Yield of Next‐Generation Sequencing: Case Series of 70 Patients

Clinical Genetics, EarlyView.
Genetic hepatic cholestasis: NGS diagnostic yield. Over a 10‐year period, NGS (gene panel/WES) established a genetic diagnosis in 70% of 66 families with hepatic cholestasis, with a molecular yield of 62%. ABCB11 was the most mutated gene, and PFIC Type 2 was the leading diagnosis, underscoring the critical role of NGS in guiding genetic counseling and
Amal Abdmouleh, Houweyda Jilani, Imen Rejeb, Syrine Hizem, Nicolas Pottier, Romain Larrue, Wendy Arondal, Lucie Hanquet, Rania Benrabeh, Olfa Bouyahia, Sonia Mazigh, Yasmina Elaribi, Lamia Benjemaa   +12 more
wiley   +1 more source

Incretin‐Based Therapies as Cardiometabolic Interventions: Outcome Hierarchy, Receptor‐Network Pharmacology and Phenotype‐Based Clinical Positioning

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Incretin‐based pharmacotherapy was initially developed to improve glucose‐dependent insulin secretion and glycaemic control in type 2 diabetes, but its clinical interpretation has expanded substantially with cardiovascular outcome trials, kidney outcome data, obesity studies and next‐generation polyagonist development.
Ferenc Sztanek, Hajnalka Lőrincz, Mariann Harangi, Attila Csaba Nagy   +3 more
wiley   +1 more source

siRNA/CS‐PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity

Advanced Science
Effective inhibition of intestinal lipid uptake is an efficient strategy for the treatment of disorders related to lipid metabolism. Sterol O‐acyltransferase 2 (SOAT2) is responsible for the esterification of free cholesterol and fatty acids into ...
Jingjia Liang, Wentao Shao, Pu Ni, Qian Liu, Weirui Kong, Weiyi Shen, Qihan Wang, Anhua Huang, Guixin Zhang, Yulong Yang, Hongliang Xin, Zhaoyan Jiang, Aihua Gu   +12 more
doaj   +1 more source

Prevalence and characteristics of gallstone disease in an Iranian population: a study on cadavers [PDF]

BACKGROUND: The prevalence of gallstones is low in Asians. In Iran, many factors influence the prevalence of this disease. The aim of this study was to determine the prevalence of gallbladder stones and their chemical characteristics in a population by ...
شیخ وطن, مهرداد, توفیقی زواره, حسن, قره داغی, جابر, فرزانه, اسماعیل   +3 more
core  

Biliary Abnormality on Imaging During Lenvatinib Plus Hepatic Arterial Infusion Chemotherapy With Cisplatin for Hepatocellular Carcinoma: A Pilot Descriptive Study

Hepatology Research, EarlyView.
ABSTRACT Aim To evaluate the frequency, imaging characteristics, associated factors, and clinical significance of biliary abnormalities on imaging in patients receiving lenvatinib (LEN) plus cisplatin hepatic arterial infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC).
Hirohito Osanai, Kazuto Kozaka, Takashi Matsubara, Norihide Yoneda, Takahiro Ogi, Kenichiro Okumura, Atsushi Takamatsu, Azusa Kitao, Shintaro Yagi, Taro Yamashita, Satoshi Kobayashi   +10 more
wiley   +1 more source

Screening gallstone disease by ultrasound decreases the necessity of cholecystectomy

, 2014
The natural history of gallstone disease plays important roles in the evaluation of screening. Therefore, the natural history of gallstone disease from no gallstone disease to cholecytectomy were quantified.
江怡德, Hsu, Chung-Te;Lien, Angela Shin-Yu;Jiang, Yi-Der;Liu, Jorn-Hon;Shih, Hui-Chuan;Luo, Jiin-Chyuan;Tung, Tao Hsin   +1 more
core  

Adaptations of glucagon‐like peptide‐1 receptor agonist‐induced weight loss, drivers of weight regain and future directions of therapeutics

The Journal of Physiology, EarlyView.
Abstract figure legend During GLP‐1RA treatment reduced appetite and energy intake, delayed gastric emptying, decreased visceral fat mass and improved glycaemic control contribute to weight loss. After treatment cessation these benefits are partially or completely reversed, resulting in weight regain, accompanied by increased appetite and energy intake,
Camille E. M. Piguet, Rosie Nucci, Jacqueline L. Beaudry   +2 more
wiley   +1 more source

Endoscopic Diagnosis of Necator americanus Infection Presenting With Persistent Iron‐Deficiency Anemia: Usefulness of Image‐Enhanced Endoscopy and Capsule Endoscopy

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Necator americanus infection is now rare in developed countries but remains an important cause of iron‐deficiency anemia and abdominal symptoms in individuals with relevant epidemiological backgrounds. A 59‐year‐old Filipino man with long‐standing unexplained iron‐deficiency anemia was admitted to our hospital for epigastric pain associated ...
Tomohiro Takebe, Satoshi Osawa, Yukihiro Watanabe, Shingo Yamagata, Takuya Aoyama, Yusuke Kawamura, Airi Manabe, Taro Kisamori, Munetaka Sano, Ken Sugimoto   +9 more
wiley   +1 more source