Results 131 to 140 of about 34,162 (209)

Clinical and Haematologic Correlates of Soluble VCAM‐1 in Adults With Steady‐State Sickle Cell Disease

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Background Endothelial activation contributes to the vasculopathy of sickle cell disease (SCD). We evaluated serum soluble vascular cell adhesion molecule‐1 (sVCAM‐1), a surrogate marker of endothelial activation, and examined its clinical and haematologic correlates in adults with steady‐state SCD.
William Kwesi Ghunney, Eugenia Vicky Asare, John Benaiah Ayete‐Nyampong, Wonder Doku‐Agama, Eric Kyei‐Baafour, Michael Fokou Ofori, George Obeng Adjei, Edeghonghon Olayemi   +7 more
wiley   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Gastrointestinal adverse effects of GLP‐1 receptor agonists and dual GIP/GLP‐1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents

Nutrition in Clinical Practice, Volume 41, Issue 5, Page 1318-1333, October 2026.
Abstract Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 receptor agonists have transformed the management of type 2 diabetes and obesity. Gastrointestinal (GI) adverse events are the most common limitation of these therapies and a leading cause of discontinuation ...
Vikash Singhani, Muhammad Ehsan, Sara Valencia, Ahmed Nadeem, Eisha Moazzam, Winfield Scott Butsch, Samita Garg   +6 more
wiley   +1 more source

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Insulin, Semaglutide and Dapagliflozin in Adults With Type 1 Diabetes: Design and Methods of Triple Therapy for Type 1 Diabetes (TTT1)—An International Phase 3 Clinical Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8812-8824, October 2026.
ABSTRACT Aims Attaining target glycaemia can be a challenge in Type 1 Diabetes (T1D) due to insulin‐induced weight gain. Adjunct therapy with modern glucose‐lowering agents developed for type 2 diabetes (T2D) has great potential but may be insufficiently efficacious and carries risks of hypoglycaemia and ketosis.
Joseph G. Timmons, Husam Ghanim, James G. Boyle, Nicola Greenlaw, Ajay Chaudhuri, Manav A. Batra, Robert S. Lindsay, Lisa Jolly, Caroline Bonner, Alex McConnachie, John R. Petrie, Paresh Dandona   +11 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Tirzepatide in Type 1 Diabetes and Obesity: Impact on Glycaemia, Weight, and Cardiometabolic Risk Markers

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8836-8846, October 2026.
ABSTRACT Aims To evaluate the effectiveness and safety of tirzepatide on glycaemia, weight, and markers of cardiometabolic risk in people with type 1 diabetes and obesity. Materials and Methods This retrospective cohort study compared 142 adults with type 1 diabetes (BMI ≥ 30 kg/m2) initiated on tirzepatide against 50 age‐, sex‐ and BMI‐matched ...
Simon A. Berry, Iona R. Goodman, Eleanor McNally, Jackie Elliott, Ahmed Iqbal   +4 more
wiley   +1 more source

Public Knowledge and Awareness of Gallstone Disease and Its Association With Self-Reported Metabolic and Lifestyle Risk Factors Among Adults in Jeddah, Saudi Arabia. [PDF]

Cureus
Mohammed SS, Alrashidi W, Ayash A, Aldaadi A, Baabdullah F, Alzahrani M, Allhyani M, Seifalyazal M.   +7 more
europepmc   +1 more source

Cholecystokinin as a novel marker of gallstones risk factor [PDF]

Introduction: cholecystokinin plays a role role in both the regulation of digestion and appetite as well as its association with the development and management of gallstones.
AM Al-Jawadi, Zena, M Al-Talib, Noor
core  

Artificially Intelligent Simulated Patients in Undergraduate Surgical Teaching: A Single Blinded Randomized Controlled Study

The Clinical Teacher, Volume 23, Issue 5, October 2026.
ABSTRACT Introduction Self‐directed learning (SDL) and reflection are critically important for clinicians. There is limited evidence describing the utilization of artificial intelligence (AI) to support medical SDL. AI simulated patients (AISP) may allow for high‐fidelity, reflective educational interactions.
W. Baraza, Georgina Staples, Cameron Wells, Louise Barbier, Isi Tonga, Parry Singh, Mike Puttick, Craig Webster   +7 more
wiley   +1 more source

The association between dietary protein and gallstones in adults under 60 years old: A cross-sectional study. [PDF]

Medicine (Baltimore)
Li Y, Liu W, Yang B, Bai L, Tang J, Zhou Y, Wu J.   +6 more
europepmc   +1 more source