Results 71 to 80 of about 830,866 (349)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

“PEMBUATAN ANIMASI NON-HUMAN CHARCTER PADA GAME MENGUNAKAN TEKNIK ANIMASI FRAME BY FRAME” [PDF]

open access: yes, 2017
Game merupakan salah satu media hiburan yang paling banyak digemari pada saat ini. Game dapat dimainkan oleh siapa saja baik anak-anak maupun orang dewasa, tergantung dari jenis game yang dipilih.
Bian Janwar F, Alumni   +1 more
core  

Video Game Characters. Theory and Analysis

open access: yesDiegesis: Interdisziplinäres E-Journal für Erzählforschung, 2014
This essay develops a method for the analysis of video game characters based on a theoretical understanding of their medium-specific representation and the mental processes involved in their intersubjective construction by video game players. We propose to distinguish, first, between narration, simulation, and communication as three modes of ...
Schröter, Felix, Thon, Jan-Noël
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Creating AI characters for fighting games using genetic programming [PDF]

open access: yes, 2016
This paper proposes a character generation approach for the M.U.G.E.N. fighting game that can create engaging AI characters using a computationally cheap process without the intervention of the expert developer.
Cant, R, Martínez-Arellano, G, Woods, D
core   +2 more sources

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick   +14 more
wiley   +1 more source

ANALISIS MODEL KECERDASAN NON PLAYER CHARACTER SEBAGAI PEMBENTUKAN CHALLANGE PADA DOTA 2 [PDF]

open access: yes, 2018
ABSTRAK Dota 2 adalah permainan Multiplayer Online Battle Arena dan Real Time Stategy merupakan subgenre dari Stategy Game. Dota 2 merupakan game permainan yang mengandalkan kemampuan kerja sama di dalam sebuah tim.
Muhamad Roni, 12.304.0265
core  

Game AI revisited [PDF]

open access: yes, 2012
More than a decade after the early research efforts on the use of artificial intelligence (AI) in computer games and the establishment of a new AI domain the term “game AI” needs to be redefined.
9th Conference on Computing Frontiers   +1 more
core   +1 more source

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