Results 31 to 40 of about 56,057 (282)

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

open access: yesAdvanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu   +8 more
wiley   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

open access: yesAdvanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang   +14 more
wiley   +1 more source

City beyond the city: the notion of contemporary flaneurism in video games [PDF]

open access: yes, 2015
This article is a comparative analysis between the exploration video game genre and the theories of contemporary city space. It focuses predominantly on confronting spatial experience of the city space with video game space.
Justyna Janik, Janik, Justyna
core   +1 more source

Influence of Gizzard Shad on Black Crappie populations in prairie impoundments of Western South Dakota

open access: yesAquaculture, Fish and Fisheries
Gizzard Shad Dorosoma cepedianum have been introduced into Western South Dakota reservoirs and shown to improve the growth and size structure of sportfish, particularly Walleye Sander vitreus. Black Crappies Pomoxis nigromaculatus are a popular sportfish
Gene Galinat, Bill Miller
doaj   +1 more source

Coproduced game-changing in transformative social innovation: reconnecting the "broken city" of Rio de Janeiro

open access: yesEcology and Society, 2017
Social innovation is gaining attention for its potential for system transformations. It is often initiated by grassroots collectives, which can become successful through support from other actors and through certain game-changing events or developments ...
Carla Cipolla   +5 more
doaj   +1 more source

Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments

open access: yesEcology and Evolution, 2022
Ecological context—the biotic and abiotic environment, along with its influence on population mixing dynamics and individual susceptibility—is thought to have major bearing on epidemic outcomes.
Kezia R. Manlove   +12 more
doaj   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen   +7 more
wiley   +1 more source

CALL: FROG - 13th Vienna Games Conference

open access: yesMedienimpulse, 2019
Während sich jährlich tausende begeisterte Spieler in der Game City im Wiener Rathaus versammeln, lädt die FROG zu einem wissenschaftlichen Diskurs zum Thema Spiele ein.
Katharina Kaiser-Müller
doaj  

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

Why Didn't I Get a Payout? Understanding Farmer Choices, Index Insurance, and Basis Risk

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Index insurance, while heralded as a potential solution to alleviate poverty and food insecurity among agricultural households, has its own set of challenges, notably basis risk. Basis risk is the discrepancy between the insurance payout and losses incurred, posing a significant deterrent to the adoption of index insurance.
S. Lucille Blakeley   +4 more
wiley   +1 more source

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