Results 41 to 50 of about 14,044,084 (355)
Automated Game Design via Conceptual Expansion [PDF]
Artificial Intelligence and Interactive Digital Entertainment Conference, 2018 Automated game design has remained a key challenge within the field of Game AI. In this paper, we introduce a method for recombining existing games to create new games through a process called conceptual expansion.Prior automated game design ...
Matthew J. Guzdial, Mark O. Riedl
semanticscholar +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Gameplay Loop Methodology as a Tool for Educational Game Design
Electronic Journal of e-Learning, 2019 The field of game design for educational content lacks a focus on methodologies that merge gameplay and learning. Existing methodologies typically fall short in three ways: they neglect the unfolding of gameplay through players’ actions over a short ...
André Czauderna
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Terms of Service: Coming to Terms with AI-Generated Art in the Classroom’ [PDF]
Athens Journal of Humanities & ArtsThis paper describes the plan and design of a new course, entitled “AI & Art.” The course introduces select tools made possible by generative artificial intelligence and large language models (LLMs).
Gregory P. Garvey
doaj +1 more source
A Guide for Game-Design-Based Gamification
Informatics, 2019 Many researchers consider Gamification as a powerful way to improve education. Many studies show improvements with respect to traditional methodologies.
F. J. Gallego-Durán +5 more
semanticscholar +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Multidimensional relationships between sensory perception and cognitive aging
Frontiers in Aging NeuroscienceA growing literature suggests that declines in sensory/perceptual systems predate cognitive declines in aging, and furthermore, they are highly predictive for developing Alzheimer’s disease and Alzheimer’s related dementias (ADRD). While vision, hearing,
Lakshmi Kannan +7 more
doaj +1 more source
Ecology and Evolution, 2020 Glacier bears are a rare grey color morph of American black bear (Ursus americanus) found only in northern Southeast Alaska and a small portion of western Canada.
Tania Lewis +4 more
doaj +1 more source