Results 71 to 80 of about 1,416,279 (345)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

A Grey-Box Approach to Automated Mechanism Design [PDF]

open access: yes, 2010
Auctions play an important role in electronic commerce, and have been used to solve problems in distributed computing. Automated approaches to designing effective auction mechanisms are helpful in reducing the burden of traditional game theoretic ...
Cai, Kai, Niu, Jinzhong, Parsons, Simon
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Gaming Science: Exploring the Intersection of Science and Video Games

open access: yesTeorie vědy
Editorial for the thematic issue Gaming Science: Exploring the Intersection of Science and Video Games.
Ivo Pezlar, Helena Bendová
doaj   +1 more source

Enable the Disabled as Technopreneur; Understanding the Challenges [PDF]

open access: yesEAI Endorsed Transactions on Creative Technologies, 2018
To achieve its target of becoming a high income country in 2020, Malaysia has taken an initiative to adoptThe Incheon Strategy to Make the Right Real for PWDs in Asia and the Pacific which comprises 10 goals, 27targets and 62 indicators to address the ...
Ruhiyati Talib   +2 more
doaj   +1 more source

Smart Games: Emergent Game Design [PDF]

open access: yes, 2021
<p>Gaming is a rapidly growing recreational activity. Over the last two decades we have seen a proliferation of games across all genres and user demographics. The consumption of content in modern games has grown as a result of the advancing technology available to game designers, as well as the growing expectations of the audience.
openaire   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick   +14 more
wiley   +1 more source

Dundee Discussion Papers in Economics 111:Do debtor-favored contracts necessarily benefit the debtor? [PDF]

open access: yes, 2000
We consider a case of security design, where the optimal contract depends on the nature of the future renegotiations game. It is shown that giving the bargaining power to the debtor in the renegotiations game may not always work in his ...
Mishra, Ajit
core  

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan   +3 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

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