Results 41 to 50 of about 68,126 (260)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Dynamic Network Model of Societal Complexity and Resilience Inspired by Tainter’s Theory of Collapse

Entropy
In recent years, several global events have severely disrupted economies and social structures, undermining confidence in the resilience of modern societies.
Florian Schunck, Marc Wiedermann, Jobst Heitzig, Jonathan F. Donges   +3 more
doaj   +1 more source

Game Theory and Literature [PDF]

Games and Economic Behavior, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Game Theory and Game Mechanics Design [PDF]

SHS Web of Conferences
This paper focuses on the significance of game balance in games and explores the application of game theory concepts for designing and analyzing balanced gameplay.
Pi Jiasheng
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

The fiducial lower confidence limits of reliability for standby system based on zero-failure data(基于无失效数据贮备系统可靠性的fiducial置信限)

Zhejiang Daxue xuebao. Lixue ban, 2010
研究元件具有无失效试验数据的贮备系统可靠性的评定问题.由无失效试验数据下元件可靠性置信下限的定义,得到元件分布参数的fiducial分布.并以此为出发点,对基于指数寿命型元件的无失效成败型试验数据、贮备系统的切换开关的成败型试验数据,在开关的成功概率分别为已知和未知的情形下,导出了由指数寿命型元件组成的贮备系统可靠性的fiducial置信下限的计算公式,并给出了算例.
JIANGRen-bin(蒋仁斌), JIANGDian-yu(姜殿玉)   +1 more
doaj   +1 more source

Evolutionary game theory [PDF]

, 1920
Article
openaire   +1 more source