Results 261 to 270 of about 110,079 (354)

Epilepsy treatment over time: The chess game analogy for choosing, adjusting, and adding antiseizure medications

Epilepsia, EarlyView.
Abstract Recurrent seizures have such a negative impact upon the lives of persons with epilepsy that their prevention is a constant preoccupation of neurologists. Despite the large number of antiseizure medications (ASMs) currently available and of publications on their putative efficacy, adverse effects, and order of preference to start treatment ...
André Palmini, André Gus, Lecio Figueira Pinto   +2 more
wiley   +1 more source

A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations.

, 1993
Richard H. ffrench‐Constant, J.C. Steichen, Thomas A. Rocheleau, Kate Aronstein, R. T. Roush   +4 more
openalex   +2 more sources

Impact of long‐term treatment with cenobamate on concomitant usage of antiseizure medications: A real‐world retrospective study in Spain

Epilepsia, EarlyView.
Abstract Objectives This study explored the safety and effectiveness of adjunctive cenobamate (CNB) in patients with different levels of drug‐resistant epilepsy (DRE) in a real‐world setting, including its impact on the use of co‐antiseizure medication (co‐ASM). Methods This was a single‐center, retrospective, observational study.
Juan María Sánchez‐Caro, Roshan Hariramani Ramchandani, Iratxe Maestro Saiz, Juan Jesús Rodríguez Uranga   +3 more
wiley   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Cognitive stagnation and executive function deficits in young children with SCN1A+ Dravet syndrome: Detailed characterization of onset, progression, and impact in the ENVISION natural history study

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy characterized by drug‐resistant seizures and developmental slowing. Although cognitive and executive function deficits have been described, their early trajectory is not well understood.
Joseph Sullivan, M. Scott Perry, Ingrid E. Scheffer, James Wheless, Susana Boronat, Andreas Brunklaus, Linda Laux, Anup D. Patel, Colin Roberts, Dennis Dlugos, Deborah Holder, Kelly Knupp, Matt Lallas, Steven Phillips, Eric Segal, Dennis Lal, Elaine Wirrell, Sameer Zuberi, Gerard Gioia, Rebecca Shaffer, Madison M. Berl, Mary Wojnaroski, Sarah Christensen, Alexander King, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico   +28 more
wiley   +1 more source

Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress. [PDF]

World J Psychiatry
Chen SH, Lan B, Zhang YY, Li GH, Qian YL, Hu MX, Tian YL, Zang WD, Cao J, Wang GH, Wang YG.   +10 more
europepmc   +1 more source

Genomic comparison of gamma-aminobutyric acid-producing Levilactobacillus brevis and Companilactobacillus zhachilii strains from Thai fermented foods

openalex   +2 more sources

Gamma-Aminobutyric Acid (Gaba) Encephalitis: Case Report

, 2017
Mohd Farid bin Md Yusof, Shalisah binti Sharip, Suriati binti Mohamed Saini, Fairuz Nazri binti Abdul Rahman, Hamid bin Abdul Rahman, Raihanah binti Abdul Khalid   +5 more
openalex   +2 more sources

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, EarlyView.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

Genome-wide transcriptomics revealed carbon source-mediated gamma-aminobutyric acid (GABA) production in a probiotic, Lactiplantibacillus pentosus 9D3. [PDF]

Heliyon
Raethong N, Chamtim P, Thananusak R, Whanmek K, Santivarangkna C.   +4 more
europepmc   +1 more source