Results 271 to 280 of about 93,041 (352)

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Structure and function of .GAMMA.-aminobutyric acid (GABA) receptor: Current state and prospectives.

, 1989
Kinya Kuriyama, Masaaki Hirouchi
openalex   +2 more sources

Optimisation of fermentation conditions for the production of gamma-aminobutyric acid (GABA)-rich soy sauce. [PDF]

Heliyon
Shin Yee C, Ilham Z, Cheng A, Abd Rahim MH, Hajar-Azhari S, Yuswan MH, Mohd Zaini NA, Reale A, Di Renzo T, Wan-Mohtar WAAQI.   +9 more
europepmc   +1 more source

Safety and effectiveness of stiripentol in patients with Dravet syndrome: A prospective, 3‐year, postmarketing surveillance study

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16285 Abstract Aim To conduct a postmarketing surveillance study of patients with Dravet syndrome in Japan to investigate the safety and effectiveness of long‐term, real‐world, clinical use of stiripentol (STP).
Yuki Kitamura, Hiroaki Ohyabu, Tatsuo Miura, Naomi Takei‐Masuda, Daisuke Matsui, Yushi Inoue, Yoko Ohtsuka   +6 more
wiley   +1 more source

Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain.

, 1992
Laurence A. Borden, Kelli E. Smith, Paul Hartig, T. A. Branchek, Richard L. Weinshank   +4 more
openalex   +1 more source

Diagnostic and therapeutic potential of tonic gamma-aminobutyric acid from reactive astrocytes in brain diseases. [PDF]

Clin Transl Med
Koh W, Lee CJ.
europepmc   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Only one of the charged amino acids located in the transmembrane alpha-helices of the gamma-aminobutyric acid transporter (subtype A) is essential for its activity.

, 1993
Shifrah Pantanowitz, Annie Bendahan, Baruch I. Kanner   +2 more
openalex   +1 more source

Intracellular Flux Prediction of Recombinant Escherichia coli Producing Gamma-Aminobutyric Acid. [PDF]

J Microbiol Biotechnol
Bae SH, Sim MS, Jeong KJ, He D, Kwon I, Kim TW, Kim HU, Choi JI.   +7 more
europepmc   +1 more source

Identification of tryptophan residues critical for the function and targeting of the gamma-aminobutyric acid transporter (subtype A).

, 1994
Nurit Kleinberger-Doron, Baruch I. Kanner   +1 more
openalex   +1 more source