Results 291 to 300 of about 93,041 (352)

Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acid_A receptors. [PDF]

Cell Death Dis
Fuhr A, Roediger R, Simelitidis M, Gamper-Tsigaras J, Templin M, Kormann M, Antkowiak B, Rudolph U, Köhler D, Rosenberger P, Ngamsri KC, Konrad FM.   +11 more
europepmc   +1 more source

Left parietal structural connectivity mediates typical and atypical language laterality in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Subjects with left temporal lobe epilepsy may either show altered hemispheric language lateralization or retain typical, left lateralization. Examining the integrity of white matter pathways involved in the adaptation or maintenance of language lateralization in these patients could have important clinical implications for preserving
Salvatore Citro, Sam S. Javidi, Ankeeta Ankeeta, Xiaosong He, Qirui Zhang, Yolanda Kry, Michael R. Sperling, Joseph I. Tracy   +7 more
wiley   +1 more source

A multicenter cohort study on the efficacy, retention, and tolerability of cenobamate in patients with developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate retention and treatment characteristics of cenobamate (CNB) in patients with developmental and epileptic encephalopathies (DEEs) in clinical practice. Methods This multicenter, retrospective cohort study recruited all patients with DEEs who started CNB treatment between October 2020 and April ...
Elisa Buhleier, Susanne Schubert‐Bast, Susanne Knake, Felix von Podewils, Hajo M. Hamer, Nico Melzer, Gerhard Kurlemann, Kerstin Alexandra Klotz, Laurent M. Willems, Felix Rosenow, Andreas Brunklaus, Adam Strzelczyk   +11 more
wiley   +1 more source

Genetic Circuits for Feedback Control of Gamma-Aminobutyric Acid Biosynthesis in Probiotic Escherichia coli Nissle 1917. [PDF]

Metabolites
Lebovich M, Lora MA, Gracia-David J, Andrews LB.   +3 more
europepmc   +1 more source

Voluntary running wheel activity reduces seizure burden and affords neuroprotection in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Physical exercise may improve neurological deficits and neuronal damage after acute brain injuries and decrease established seizures. We investigated whether voluntary running wheel (RW) activity affects epileptogenesis in a mouse model of acquired epilepsy compared to sedentary mice.
Valentina Kebede, Rossella Di Sapia, Nicole Tonesi, Massimo Rizzi, Silvia Balosso, Daniele Spallaci, Ilaria Craparotta, Laura Pasetto, Valentina Bonetto, Gerardo Marsella, Luca Porcu, Giorgio Rosati, Alessandro Ieraci, Annamaria Vezzani   +13 more
wiley   +1 more source

Chronic optogenetic stimulation of dentate gyrus granule cells in mouse organotypic slice cultures synaptically drives mossy cell degeneration

Epilepsia, EarlyView.
Abstract Objective Degeneration of hilar mossy cells in the dentate gyrus is an important hallmark of hippocampal sclerosis and is often observed in patients with temporal lobe epilepsy. To understand the pathogenesis of hippocampal sclerosis and develop novel neuroprotective treatments, it is critical to determine the mechanistic processes of mossy ...
Carolin Christina Koretz, Rebecca Schneider, Tassilo Jungenitz, Alexander Drakew, Jochen Roeper, Thomas Deller   +5 more
wiley   +1 more source

Screening and characterization of lactic acid bacteria and fermentation of gamma-aminobutyric acid-enriched bamboo shoots. [PDF]

Front Microbiol
Chen M, Xia H, Zuo X, Tang D, Zhou H, Huang Z, Guo A, Lv J.   +7 more
europepmc   +1 more source

The cerebellum in epilepsy

Epilepsia, EarlyView.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source

Cellulase Promotes Mycobacterial Biofilm Dispersal in Response to a Decrease in the Bacterial Metabolite Gamma-Aminobutyric Acid. [PDF]

Int J Mol Sci
Zhang J, Liu Y, Hu J, Leng G, Liu X, Cui Z, Wang W, Ma Y, Sha S.   +8 more
europepmc   +1 more source

ENX‐101, a GABAA receptor α2,3,5‐selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acid type A (GABAA) receptor positive allosteric modulators (PAMs) that lack α‐subunit selectivity, including benzodiazepines such as diazepam, exhibit antiseizure actions in animal models and in humans. ENX‐101 is a deuterated analog of the ⍺2,3,5‐selective GABAA receptor PAM L‐838,417.
Jordi Serrats, Krishna C. Vadodaria, William Brubaker, Melissa Barker‐Haliski, H. Steve White, Alexis Evrard, Corinne Roucard, Eve Taylor, Kimberly E. Vanover, Stephen Cunningham, Vikram Sudarsan, Michael A. Rogawski   +11 more
wiley   +1 more source