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Metabolism and functions of gamma-aminobutyric acid
Trends in Plant Science, 1999Gamma-aminobutyric acid (GABA), a four-carbon non-protein amino acid, is a significant component of the free amino acid pool in most prokaryotic and eukaryotic organisms. In plants, stress initiates a signal-transduction pathway, in which increased cytosolic Ca2+ activates Ca2+/calmodulin-dependent glutamate decarboxylase activity and GABA synthesis ...
Alan W. Bown+2 more
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Gamma-Aminobutyric Acid and the Liver
Digestive Diseases, 1993Gamma-aminobutyric acid (GABA) is a potent amino acid neurotransmitter with various physiologic effects throughout the body. Over the past 40 years it has become evident that the mammalian liver contains high concentrations of GABA which are carefully regulated by a series of hepatic metabolic pathways and a specific sodium-dependent active transport ...
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Gamma-Aminobutyric Acid (GABA) and Sleep
European Neurology, 1977The effects of di-n-propylacetic acid (DPA) on sleep, for some years used as an anticonvulsive drug, has been investigated in 11 healthy volunteers using all-night sleep EEG recordings.
Ziegler B, E. Schneider, H. Maxion
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Gamma‐aminobutyric acid in the nervous system of a planarian
Journal of Comparative Neurology, 1994AbstractThe amino acid gamma‐aminobutyric acid (GABA) is an important inhibitory neurotransmitter in both vertebrates and invertebrates. Despite this, no reports of GABA in flatworms have to date been published. We have studied the presence of GABA in the planarian Dugesia tigrina with immunocytochemical methods and high‐pressure liquid chromatography.
Perm Panula, Krister Eriksson
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Gamma-Aminobutyric Acid as a Neurotrophic Agent [PDF]
There is accumulating evidence that different classical neurotransmitters such as serotonin, catecholamines and the amino acid GABA may serve as epigenetic factors during neuronal development and differentiation (1, 2, 3, 4). Since a variety of macromolecular compounds, mainly peptides, are also known to act as neurotrophic factors (5) it is clear that
R. Hammerschlag+4 more
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The determination of gamma-aminobutyric acid in brain
Analytical Biochemistry, 1962Abstract A simple method for the determination of γ-aminobutyric acid in brain tissue is described. Two columns of ion-exchange resin are used. An extract of rat brain is first passed through Amberlite CG-50, which removes basic amino acids and amines.
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Immunostimulating property of gamma-aminobutyric acid
Bulletin of Experimental Biology and Medicine, 1987The writers previously [2, 3] showed that 9 of the 20 amino acids present in the composition of proteins (Asp, Asn, Glu, Cys, Set, Thr, Trp, Ala, Val) can induce Thy-I-antigen on bone marrow cells and can stimulate the sinus-dependent immune response in mice.
G. A. Belokrylov, I. V. Molchanova
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Inhibition of a gamma aminobutyric acid A receptor by caffeine
NeuroReport, 1994The effect of caffeine was studied on the progress of gamma aminobutyric acid A receptor channel (GABAAR) mediated transmembrane 36Cl-flux and [3H]GABA release in native membrane vesicles from rat cerebral cortex using rapid kinetic techniques. GABA response on the second time-scale mediated by the slower desensitizing GABAAR was inactivated by 5 mM ...
Tamás Blandl, Julianna Kardos
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IONS AND THE TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES
Journal of Neurochemistry, 1972Abstract— The initial rate of uptake of [2,3‐3H]gamma‐aminobutyric acid by rat brain synaptosomes was studied under incubation conditions in which GABA metabolism was minimal. The presence of both sodium and potassium in the incubation medium was essential for sustained uptake. Uptake proceeded for a short period of time in the absence of potassium and
A. A. Smith, David L. Martin
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