Results 191 to 200 of about 16,806 (319)

Ultrasensitive Detection of FKBP12 Using a Synthetic Receptor‐Functionalized QCM Nanoplatform

open access: yesAdvanced Sensor Research, Volume 4, Issue 10, October 2025.
A reusable nanosensor platform for ultralow FKBP12 detection in physiological fluids is presented. Combining a gold‐coated QCM with a custom‐designed receptor in a self‐assembled monolayer, the device achieves picomolar sensitivity and high selectivity.
Martina Tozzetti   +8 more
wiley   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang   +14 more
wiley   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen   +16 more
wiley   +1 more source

Weaning as Stressor for Calf Welfare. [PDF]

open access: yesAnimals (Basel)
Guasco C   +7 more
europepmc   +1 more source

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