Results 41 to 50 of about 9,163 (225)

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

Biotechnology and Bioengineering, Volume 123, Issue 5, Page 1236-1265, May 2026.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan, Marco P․ C․ Marques, Ana M. Azevedo, Daniel G. Bracewell, Stephen Goldrick   +4 more
wiley   +1 more source

Study of plasma amino acid levels in children with autism: An Egyptian sample

Egyptian Journal of Medical Human Genetics, 2014
Background: The aetiology of autism is unclear and autistic symptoms had been attributed to an abnormal functional imbalance in neurotransmitter amines such as dopamine, noradrenaline and serotonin.
Farida M. ElBaz, Mona M. Zaki, Azza M. Youssef, Ghada F. ElDorry, Dina Y. Elalfy   +4 more
doaj   +1 more source

Image analysis method for measurement and prediction of intra‐matrix IgG diffusion

Biotechnology Progress, EarlyView.
Experimental and image analysis workflow for b‐IgG diffusion in hyaluronic acid (HA) matrix. Abstract Measurement and imaging of intra‐matrix protein therapeutics diffusion is important due to the emergence of injectable biologics currently in various stages of research and clinical testing.
Riya Debbarma, Antonio C. F. dos Santos, Michael Ladisch   +2 more
wiley   +1 more source

Colostrum quality in Northern Italy: The role of dry cow nutrition and colostrum feeding management

Czech Journal of Animal Science
This study investigated the effects of dry cow feeding on colostrum quality. A survey was conducted, and samples of colostrum and feed ingredients were collected from 25 dairy farms in Northern Italy.
Martina Pavesi, Giulia Gislon, Serena Bonizzi, Stefania Colombini, Nicola Palladini, Maddalena Zucali   +5 more
doaj   +1 more source

INVESTIGATION ON AN OUTBREAK OF ENZOOTIC BRONCHPNEUMONIA IN BUFFALO CALVES IN ASSIUT, EGYPT, A.R.E. II - CLINICAL SIGNIFICANCE OF BLOOD SERUM PROTEIN LEVELS AND ELECTROPHORETIC SERUM PROTEIN FRACTIONATION IN INFECTED CALVES [PDF]

Assiut Veterinary Medical Journal, 1984
This investigation was carried out on a total twelve calves. Eight buffalo calves 9-12 months of age were isolated showing severe respiratory distress, while four animals (appar ently healthy) served as control.
N.K. HASSAAN, A. EL-SEBAIE
doaj   +1 more source

Gamma globulin metabolism in rabbits immunized with autologous denatured gamma globulin [PDF]

Arthritis & Rheumatism, 1965
AbstractAntibodies resembling rheumatoid factor (RF) were produced in rabbits by immunization with alkali denatured autologous gamma globulin (RGG) in Freund's adjuvant. Gamma globulin metabolism was studied with I131 labeled gamma globulin in 5 such rabbits and in 4 control rabbits treated with Freund's adjuvant alone.
E A, CATSOULIS, M A, ROTHSCHILD, M, ORATZ, E C, FRANKLIN   +3 more
openaire   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Assessing Clinical Severity and Prognosis in Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa Using the Albumin‐Globulin Ratio

European Eating Disorders Review, EarlyView.
ABSTRACT Objective The albumin‐globulin ratio (AGR) is a biochemical marker reflecting nutritional and inflammatory status, with significant prognostic value in chronic conditions. This study examined its association with clinical/biochemical markers in adolescents with anorexia nervosa (AN) and atypical AN (AAN).
Eylem Şerife Kalkan, Ayşe Bilge Baklaci, Yelda Kiliç, Sinem Akgül, Nilgün Özgül, Melis Pehlivanturk Kizilkan   +5 more
wiley   +1 more source