Results 1 to 10 of about 10,731 (180)

Severe Polymicrobial Pneumonia With Septicemia After Interruption of Immunoglobulin Replacement in X‐Linked Agammaglobulinemia: A Case Report [PDF]

Case Reports in Immunology, Volume 2026, Issue 1, 2026.
Background X‐linked agammaglobulinemia (XLA) is an inherited primary immunodeficiency characterized by impaired B‐cell maturation, profound hypogammaglobulinemia, and susceptibility to recurrent bacterial infections. Lifelong immunoglobulin replacement therapy (IGRT) is essential to reduce infectious complications, but treatment interruptions may ...
Hau Dinh Tran, Quang Hung Vo, Nghia Phu Nguyen, Guangzu Zhao   +3 more
wiley   +2 more sources

JOINT DISEASE IN CHILDREN WITH X-LINKED AGAMMAGLOBULINEMIA

Journal of IMAB, 2013
Patients with X-linked agammaglobulinemia (XLA) are prone to recurrent bacterial infections due to low levels of immunoglobulins. Clinical symptoms include recurrent bacterial otitis media, bronchitis, pneumonia, meningitis, skin infection and arthritis ...
Lidija Kareva, Kristina Mironska, Katarina Stavric   +2 more
doaj   +2 more sources

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

A State of the Art Review on the Recalcitrant Candidiasis as a Clue of Inborn Errors of Immunity in Newborns

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Defects in the development or function of the immune system are characteristic of inborn errors of immunity (IEI), a diverse group of inherited disorders. IEI can manifest in various ways during the neonatal stage, posing a challenge in their identification and treatment. The family who have a background of IEI, including a previous instance
Mahsa Fattahi, Pegah Tamimi, Aliasghar Ghaderi, Mohammad Reza Fazlollahi, Zahra Pourpak, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

FNIP1 Deficiency: Pathophysiology and Clinical Manifestations of a Rare Syndromic Primary Immunodeficiency

Current Issues in Molecular Biology
Folliculin-interacting protein 1 (FNIP1) is a key regulator of cellular metabolism and immune homeostasis, integrating nutrient signaling with proteostasis.
Samuele Roncareggi, Brian M. Iritani, Francesco Saettini   +2 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, Volume 66, Issue S2, Page 121-143, December 2025.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, Volume 12, Issue 11, Page 2358-2366, November 2025.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Duodenal nodular lymphoid hyperplasia in a patient with IgA deficiency

Clinical Case Reports, 2020
Most patients with IgA deficiency are asymptomatic, but duodenal nodular lymphoid hyperplasia is one symptom known to be associated with common variable immunodeficiency (CVID), including selective IgA deficiency and agammaglobulinemia.
Hanae Ida, Dai Maruyama, Akiko Miyagi Maeshima, Takahiro Kamiya, Tomohiro Morio, Koji Izutsu   +5 more
doaj   +1 more source

A clinical case of autosomal recessive agammaglobulinemia with B-cell deficiency

Аллергология и Иммунология в Педиатрии
Background. Primary agammaglobulinemia is the result of specific changes in B-cells that lead to low antibody production. A preliminary diagnosis is established if there is a history of frequent bacterial infections (otitis media, sinusitis, skin ...
E. V. Negodnova, M. S. Iskandyarova, E. N. Tyagusheva, O. A. Radaeva, G. V. Fominova   +4 more
doaj   +1 more source

Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study

Biomédica: revista del Instituto Nacional de Salud
Introduction. Immunodeficiencies are disturbances in the immune system that can affect cell function, quantity, or both. They can be either primary, associated with genetic defects, or secondary, linked to external factors such as hemato-oncological ...
Ana Lucía Guzmán, Isabella Villamil, Sofía Martínez-Betancur, Oriana Arias-Valderrama, Jacobo Triviño-Arias, Jessica Largo, Viviana Lotero, Alexis Franco, Ximena Castro, Pamela Rodríguez, Luz Angela Urcuqui, Diego Medina, Manuela Olaya   +12 more
doaj   +1 more source