Results 71 to 80 of about 758,388 (335)

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Multiple sclerosis with early childhood onset: a case report

Arquivos de Neuro-Psiquiatria, 1988
A 2 year old boy was admitted owing to a subacute episode of ataxic gait and hearing deficit. Computerized tomography (CT) was normal and cerebrospinal fluid (CSF) analysis revealed gamma globul.ns level of 15.4% (normal 7 to 14%).
Maria Isabel Campos Vergani, Rubens Reimão, Ana Maria Camara Silva, Mauro Muskat, Sandro Espósito, Aron Diament   +5 more
doaj   +1 more source

Effects of Temperature and Crowding on the Pathogenicity of Edwardsiella ictaluri in Channel Catfish (Ictalurus punctatus) [PDF]

, 1985
Channel catfish were injected with Edwardsiella ictaluri and stocked at increasing temperatures and densities. Bacteriological examination of kidney, liver and spleen revealed the greatest numbers of organisms in fish from the highest temperature and ...
Hinck, Lawrence W., Johnson, Sharon L.
core   +2 more sources

Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins.

Proceedings of the National Academy of Sciences of the United States of America, 1974
The complete amino acid sequence of the heavy chain variable regions of two different molecules of immunoglobulin M anti-gamma globulin has been determined.
J. Capra, J. Kehoe
semanticscholar   +1 more source

Enhanced Multitask Learning with Attention Sparse Routing Mechanism for Intelligent Diabetes Prediction

Advanced Intelligent Systems, EarlyView.
The model leverages patient time‐space information for pattern feature representations. Encoders extract first and second‐order features, aggregated with categorical embeddings and dense features. Task‐specific and shared experts use gated networks, with a dispatch layer routing information for diabetes risk evaluation and blood glucose prediction ...
Yingshuai Wang, Hongpu Hu, Liqin Xie, Qingkun Chen, Xingyun Lei, Panpan Qin, Yan Wang, Xing Gao, Yanli Wan   +8 more
wiley   +1 more source

Isolation and characterization of a light chain variable region gene for human rheumatoid factors. [PDF]

, 1987
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF ...
Carson, DA, Chen, PP, Jirik, FR, Kipps, TJ, Robbins, DL   +4 more
core  

The nature of Bence-Jones proteins. Chemical similarities to polypetide chains of myeloma globulins and normal gamma-globulins.

, 1962
The chemical relations among Bence-Jones proteins, myeloma proteins, and normal γ-globulins have been investigated by a variety of means. Starch gel electrophoresis in 8 M urea of reduced alkylated Bence-Jones proteins yielded patterns of bands ...
G. M. Delman, J. Gally
semanticscholar   +1 more source

Clinlabomics‐Enabled Blending Ensemble Learning for Low‐Cost Pan‐Cancer Detection and Classification Using Routine Clinical Laboratory Data

Advanced Intelligent Systems, EarlyView.
Researchers develop clinlabomics assisted for cancer identification, an artificial intelligence‐powered system using routine clinical lab data to detect and identify 10 cancer types. Tested on 19 199 individuals, it achieves 90.39% sensitivity and 82.41% specificity in cancer detection, with 72.57% accuracy in identifying specific cancer types ...
Bowen Zhang, Lin Li, Long Cheng, Yujie Liu, Zhaoqing Liu, Jiangpeng Wu, Pengyi Zhang, Jiarui Wang, Dekui Zhang, Shuyan Li   +9 more
wiley   +1 more source

Haematological and Serum Protein Values in Tuberculin Reactor and Non-Reactor Water Buffaloes, Cattle, Sheep and Goats [PDF]

Pakistan Veterinary Journal, 2010
The diagnostic accuracy of tuberculosis can be enhanced by new tests like gamma interferon used in conjunction with tuberculin test but these tests are quite expensive to be conducted on all animals in resource poor countries.
M. Tariq Javed*, L. Ahmad, M. Irfan, I. Ali, A. Khan, M. Wasiq, F. A. Farooqi, A. Latif Shahid and M. Cagiola2
doaj  

Hematological and serum biochemical aspects associated with a camel (Camelus dromedarius) naturally infected by Trypanosoma evansi with severe parasitemia in Semnan, Iran

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To determine the presence of Trypanosoma evansi (T. evansi) and the effect of trypanosomosis on hemato-biochemical profile of dromedary camels in Semnan, Iran, which has not been reported yet.
Mahmood Ahmadi-hamedani, Khosro Ghazvinian, Mohammad Mehdi Darvishi   +2 more
doaj   +1 more source