Results 91 to 100 of about 25,697 (258)
Hepatology Communications, 2018 Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist for children with PSC.
Mark R. Deneau +41 more
doaj +1 more source
Hepatology Research, EarlyView.It is speculated that the onset of obesity‐related diseases follows the sequence of obesity → SLD → MetS‐related diseases. In this study, the contribution of SLD to each MetS‐related disease was large for T2D and hypertension and SLD contributed to the onset and new onset of the disease by the 7‐year follow‐up.
Yoshihiro Kamada +6 more
wiley +1 more source
Correlates and reference limits of plasma gamma-glutamyltransferase fractions from the Framingham Heart Study. [PDF]
, 2013 Background: We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study. Methods: Correlates of GGT fractions were assessed by multivariable regression analysis in 3203 individuals [47% men ...
EMDIN, MICHELE +7 more
core +1 more source
Immunology &Cell Biology, EarlyView.In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
The natural history of primary sclerosing cholangitis in 781 children. A multicenter, international collaboration [PDF]
, 2017 There are limited data on the natural history of primary sclerosing cholangitis (PSC) in children. We aimed to describe the disease characteristics and long-term outcomes of pediatric PSC.
Abdou, Reham +45 more
core +2 more sources
Bimekizumab efficacy and safety in Chinese patients with psoriasis in the BE SHINING Phase 3 study
Journal of the European Academy of Dermatology and Venereology, EarlyView.In Chinese patients with moderate to severe plaque psoriasis, bimekizumab treatment was well tolerated and led to significantly higher clinical response rates versus placebo, including complete skin clearance. These findings were consistent with global studies and suggest that bimekizumab is an effective treatment option for Chinese people living with ...
Lin Cai +11 more
wiley +1 more source
Serum gamma-glutamyltransferase fractions in Myotonic Dystrophy type I: Differences with healthy subjects and patients with liver disease. [PDF]
, 2010 Objectives: Elevation of serum gamma-glutamyltransferase (GGT), in absence of a clinically significant liver damage, is often found in Myotonic Dystrophy type-1 (DM1). In this study we investigated if a specific GGT fraction pattern is present in DM1.
Baggiani A +13 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1502-1516, April 2026.Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy +10 more
wiley +1 more source
Association between noninvasive fibrosis markers and cardio-vascular organ damage among adults with hepatic steatosis [PDF]
, 2014 Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage)
Fiorentino, Tv +5 more
core +2 more sources