Results 91 to 100 of about 72,034 (329)

Multiwavelength Analysis of the Supernova-associated Low-luminosity GRB 171205A

open access: yesThe Astrophysical Journal
Multiwavelength properties of the nearby supernova (SN)-associated low-luminosity GRB 171205A are investigated in depth to constrain its physical origin synthetically. The pulse width is found to be correlated with energy with a power-law index of −0.24 ±
Xiu-Juan Li   +3 more
doaj   +1 more source

The supernova/gamma-ray burst/jet connection

open access: yes, 2013
The observed association between supernovae and gamma-ray bursts represents a cornerstone in our understanding of the nature of gamma-ray bursts. The collapsar model provides a theoretical framework for this connection.
Hjorth, Jens
core   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

open access: yesAdvanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li   +6 more
wiley   +1 more source

Comprehensive Statistical Analysis of Initial Lorentz Factor and Jet Opening Angle of Gamma-Ray Bursts

open access: yesThe Astrophysical Journal
The initial Lorentz factor (Γ _0 ) and jet half-opening angle ( θ _jet ) of gamma-ray bursts (GRBs) are critical physical parameters for understanding the dynamical evolution of relativistic jets and the true energy release of GRBs.
Jian Zhang   +3 more
doaj   +1 more source

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang   +8 more
wiley   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

open access: yesAdvanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza   +19 more
wiley   +1 more source

RapidGBM: An Efficient Tool for Fermi-GBM Visibility Checking and Data Analysis with a Case Study of EP240617a

open access: yesThe Astrophysical Journal
We have developed a lightweight tool, RapidGBM , featuring a web-based interface and capabilities of rapid calculation of Fermi Gamma-ray Burst Monitor (GBM) visibilities and performance of basic data analysis.
Yun Wang   +17 more
doaj   +1 more source

EXTRAGALACTIC GAMMA-RAYS: GAMMA RAY BURSTS AND BLAZARS

open access: yesInternational Journal of Modern Physics A, 2005
The extragalactic gamma-ray sky is dominated by two classes of sources: Gamma-Ray Bursts (GRBs) and radio loud active galactic nuclei whose jets are pointing at us (blazars). We believe that the radiation we receive from them originates from the transformation of bulk relativistic energy into random energy.
openaire   +2 more sources

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang   +8 more
wiley   +1 more source

A Gravitational Millilensing Candidate in GRB 111012A with a Possible Compact Merger Origin

open access: yesThe Astrophysical Journal
We identify GRB 111012A in the Fermi Gamma-ray Burst Monitor archive as a candidate case of gravitational millilensing. The burst shows two pulses separated by ∼3.1 s, reminiscent of previously reported lensed events such as GRB 950830 and GRB 200716C ...
Shuo Xiao   +7 more
doaj   +1 more source

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