Results 81 to 90 of about 1,406,358 (336)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Parameterized Finite Binomial Sums

Mathematics
We offer intriguing new insights into parameterized finite binomial sums, revealing elegant identities such as ∑k=0,k≠nm+n(−1)kn−km+nk=(−1)nm+nn(Hm−Hn), where n,m are non-negative integers and Hn is the harmonic number. These formulas beautifully capture
Necdet Batır, Junesang Choi
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

On a (p,k)-analogue of the Gamma function and some associated Inequalities

Moroccan Journal of Pure and Applied Analysis, 2016
In this paper, we introduce a new two-parameter deformation of the classical Gamma function, which we call a (p,k)-analogue of the Gamma function. We also provide some identities generalizing those satisfied by the classical Gamma function.
Nantomah K., Prempeh E., Twum S. B.
doaj   +1 more source

Bounds for triple gamma functions and their ratios

Journal of Inequalities and Applications, 2016
In this work, in addition to the bounds for triple gamma function, bounds for the ratios of triple gamma functions are obtained. Similar bounds for the ratios of the double gamma functions are also obtained.
Sourav Das, A Swaminathan
doaj   +1 more source

The $c\bar c$ interaction above threshold and the radiative decay $X(3872)\rightarrow J/\psi\gamma$

, 2015
Radiative decays of $X(3872)$ are studied in single-channel approximation (SCA) and in the coupled-channel (CC) approach, where the decay channels $D\bar D^*$ are described with the string breaking mechanism. In SCA the transition rate $\tilde{\Gamma}_2=\
Badalian, A. M., Bakker, B. L. G, Simonov, Yu. A.   +2 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Symmetries of WDVV equations

, 2005
We say that a function F(tau) obeys WDVV equations, if for a given invertible symmetric matrix eta^{alpha beta} and all tau \in T \subset R^n, the expressions c^{alpha}_{beta gamma}(tau) = eta^{alpha lambda} c_{lambda beta gamma}(tau) = eta^{alpha lambda}
Albert Schwarz, Barannikov, Dijkgraaf, Dubrovin, Givental, Maxim Kontsevich, van de Leur, Yujun Chen   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A completely monotonic function involving the gamma and trigamma functions

Kuwait Journal of Science, 2016
In the paper the author provides necessary and sufficient conditions on $a$ for the function\begin{equation*}\frac{1}{2}\ln(2\pi)-x+\biggl(x-\frac{1}{2}\biggr)\ln x-\ln\Gamma(x)+\frac1{12}{\psi'(x+a)}\end{equation*}and its negative to be completely ...
Feng Qi
doaj