Results 41 to 50 of about 234,241 (214)

Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009-2010).

PLoS ONE, 2017
High levels of gamma glutamyltransferase (gamma-GT) and alanine aminotransferase (ALT), as well as fatty liver index (FLI) has been associated with higher cardiovascular disease risk factors in adults.
Antonio García-Hermoso, Anthony C Hackney, Robinson Ramírez-Vélez   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Inadequacy of the gamma distribution to calculate the Standardized Precipitation Index

Revista Brasileira de Engenharia Agrícola e Ambiental, 2015
The Standardized Precipitation Index was developed as a probability-based index able to monitor rainfall deficit in a standardized or normalized way.
Gabriel C. Blain, Monica C. Meschiatti
doaj   +1 more source

Distance from fractional Brownian motion with associated Hurst index $0\mathrm{<}\mathit{H}\mathrm{<}1\mathrm{/}2$ to the subspaces of Gaussian martingales involving power integrands with an arbitrary positive exponent

Modern Stochastics: Theory and Applications, 2020
We find the best approximation of the fractional Brownian motion with the Hurst index $H\in (0,1/2)$ by Gaussian martingales of the form ${\textstyle\int _{0}^{t}}{s^{\gamma }}d{W_{s}}$, where W is a Wiener process, $\gamma >0$.
Oksana Banna, Filipp Buryak, Yuliya Mishura   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Influence of magnetic field and temperature on negative refractive index in a degenerate three-level atomic system

Communications in Physics
This work investigates the manipulation of the negative refractive index in a degenerate three-level \( \Lambda \)-type atomic system in the presence of an external magnetic field and Doppler broadening.
Bang Nguyen Huy, Luong Thi Yen Nga, Ai Nguyen Van, Van Phu Nguyen, Duc Thuan Phan, Doai Le Van   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A note on fixed points of automorphisms of infinite groups [PDF]

International Journal of Group Theory, 2014
Motivated by a celebrated theorem of Schur, we show that if $Gamma$ is a normal subgroup of the full automorphism group $Aut(G)$ of a group $G$ such that $Inn(G)$ is contained in $Gamma$ and $Aut(G)/Gamma$ has no uncountable abelian subgroups of prime ...
Francesco de Giovanni , Martin L. Newell, Alessio Russo   +2 more
doaj  

IGMRES method for linear systems [PDF]

Journal of Mahani Mathematical Research
The Index Generalized Minimal RESidual (IGMRES) algorithm is designed to compute the Drazin-inverse solution of a linear system of equations $Ax=b$, where $A$ is an arbitrary square matrix with index $\gamma$.
Faranges Kyanfar
doaj   +1 more source