Results 21 to 30 of about 15,435 (232)
Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation
Advanced Science, EarlyView.A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou +12 more
wiley +1 more source
Case Reports in Neurological Medicine, 2012 Brain metastases are the most common cancerous neoplasm in the brain. The treatment of these lesions is challenging and often includes a multimodality management approach with whole-brain radiation therapy, stereotactic radiosurgery, and neurosurgery ...
Ameer L. Elaimy +8 more
doaj +1 more source
Case Reports in Medicine, 2020 We present a unique case of a patient simultaneously diagnosed with solitary fibrous tumor (SFT) and unrelated adenocarcinoma of the lung, both proven with separate pathology.
Erin A. Kaya +6 more
doaj +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Case Reports in Medicine, 2012 The management of recurrent glioblastoma is highly challenging, and treatment outcomes remain uniformly poor. Glioblastoma is a highly infiltrative tumor, and complete surgical resection of all microscopic extensions cannot be achieved at the time of ...
Sudheer R. Thumma +8 more
doaj +1 more source
Advanced Science, EarlyView.Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang +11 more
wiley +1 more source
Radiation Oncology, 2022 Background Recently, stereotacitc radiosurgery (SRS) has been in the spotlight as an alternative therapeutic option for jugular foramen schwannomas (JFS). While most reported studies focus on the long-term efficacy and safety issues of SRS, none describe
Young Goo Kim +6 more
doaj +1 more source
Advanced Science, EarlyView.Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu +9 more
wiley +1 more source
Dysphagia, dysphonia & dyspnoe caused by ostrich beak-like anterior C1-C2 cervical osteophyte
Interdisciplinary Neurosurgery, 2019 Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's disease is associated with cervical osteophytes, most commonly at the C5–6 level. We report a large beak-like anterior osteophyte at C1/C2 level presenting with severe dysphagia, dysphonia ...
Hardik Sardana, M.Ch. +4 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo +6 more
wiley +1 more source