Results 81 to 90 of about 1,029,566 (295)
Length functions of Hitchin representations
, 2013 Given a Hitchin representation $\rho \colon \pi_1(S) \to \PSL_n(\mathbb{R})$, we construct $n$ continuous functions $\ell_i^\rho \colon \mathcal \CH(S) \to \mathbb{R}$ defined on the space of H\"older geodesic currents $\CH(S)$ such that, for a closed ...
Bridson +7 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Sensors, 2023 Gamma imagers play a key role in both industrial and medical applications. Modern gamma imagers typically employ iterative reconstruction methods in which the system matrix (SM) is a key component to obtain high-quality images.
Yihang Zhu +4 more
doaj +1 more source
Materials & Design, 2017 Abstract Functional shielding filler modified fiber reinforced polymer matrix composites are novel structural/radiation shielding materials with great potentials in applications such as nuclear industry and radioactive therapy. In this study, unidirectional basalt fiber reinforced epoxy resin matrix composite laminates containing different contents ...
Ran Li +5 more
openaire +1 more source
Corrigendum to ‛Beta and gamma dose rate attenuation in rocks and sediment’
Radiation Measurements, 2020 This paper explores the attenuation of beta and gamma dose rate in a radioactive and in an adjacent inert layer for K, Th and U, individually, using Geant4 simulations.
S. Riedesel, M. Autzen
semanticscholar +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source