Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease [PDF]
Frontiers in Molecular Neuroscience, 2023 Recent clinical data with three therapeutic anti-Aβ antibodies have demonstrated that removal of Aβ-amyloid plaques in early Alzheimer's disease (AD) can attenuate disease progression.
Gunnar Nordvall +6 more
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Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. [PDF]
PLoS Biology, 2008 The presenilin/gamma-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover.
Matthew L Hemming +3 more
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Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis [PDF]
Emerging Microbes and Infections, 2021 Cutaneous leishmaniasis (CL) patients present an exacerbated inflammatory response associated with tissue damage and ulcer development. Increasing numbers of patients have exhibited treatment failure, which remains not well understood.
Maurício T. Nascimento +8 more
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Activity of the Gamma Secretase Inhibitor AL101 in Desmoid Tumors: A Case Report of 2 Adult Cases [PDF]
Current Oncology, 2021 Desmoid tumors (aggressive fibromatosis) are soft tissue mesenchymal tumors that can be locally invasive and life-threatening. Depending on the location, these tumors are often unresectable or tend to recur after surgery.
David Chan +3 more
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Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification [PDF]
Journal of Orthopaedic Translation, 2023 Background: Traumatic heterotopic ossification (THO) is a devastating sequela following traumatic injuries and orthopedic surgeries. To date, the exact molecular mechanism of THO formation is still unclear, which hinders the development of effective ...
Zheng Wang +6 more
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Identification of presenilin mutations that have sufficient gamma-secretase proteolytic activity to mediate Notch signaling but disrupt organelle and neuronal health [PDF]
Neurobiology of DiseaseMutations that cause familial Alzheimer's disease (AD) are predominantly found in the presenilin (PSEN) encoding genes PSEN1 and PSEN2. While the association of PSEN mutations with familial AD have been known for over 20 years, the mechanism underlying ...
Zahra Ashkavand +5 more
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PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia [PDF]
Journal of Hematology & Oncology, 2021 Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and are predicted to be
Inge Govaerts +11 more
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Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury [PDF]
Frontiers in Cell and Developmental Biology, 2020 In a recent study, we showed that GABA and baclofen (a GABAB receptor agonist) inhibit caspase activation and promote axon regeneration in descending neurons of the sea lamprey brainstem after a complete spinal cord injury (Romaus-Sanjurjo et al., 2018a).
Daniel Sobrido-Cameán +6 more
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Synaptic and endosomal localization of active gamma-secretase in rat brain. [PDF]
PLoS ONE, 2010 A key player in the development of Alzheimer's disease (AD) is the gamma-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2.
Susanne Frykman +7 more
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Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. [PDF]
PLoS ONE, 2009 Alzheimer disease (AD) is an age-related disorder. Aging and female gender are two important risk factors associated with sporadic AD. However, the mechanism by which aging and gender contribute to the pathogenesis of sporadic AD is unclear.
Lisa Placanica, Lei Zhu, Yue-Ming Li
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