Results 91 to 100 of about 25,969 (247)

Contemporary Management of Malignancies of the Parotid Gland: A State‐of‐the‐Art Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objectives To provide a systematic update on the contemporary management of malignancies of the parotid gland (MPG), focusing on evidence‐based practices and emerging therapeutics. Data Sources PubMed literature search. Review Methods A search protocol was designed according to the Preferred Reporting Items for Systematic Reviews and Meta ...
Anthony Tang, Vanessa Helou, Shaum S. Sridharan, Renata Ferrarotto, Jessica L. Geiger, Dan P. Zandberg, Diana Bell, Heath Skinner, Matthew E. Spector, Eugene N. Myers, Kevin J. Contrera   +10 more
wiley   +1 more source

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound [PDF]

, 2010
The accumulation of amyloid beta (Aβ) in Alzheimer’s disease is caused by an imbalance of production and clearance, which leads to increased soluble Aβ species and extracellular plaque formation in the brain.
Bateman, Randall J, Cook, Jacquelynn J, Gilberto, David B, Holahan, Marie A, Kinney, Gene G, Mathers, Parker D, Michener, Maria S, Price, Eric A, Shearman, Mark S, Simon, Adam J, Wang, Jennifer X, Wildsmith, Kristin R, Wu, Guoxin, Yarasheski, Kevin E   +13 more
core   +2 more sources

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, EarlyView.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

Molecular Neurodegeneration, 2010
Background The mutation in Huntington's disease is a polyglutamine expansion near the N-terminus of huntingtin. Huntingtin expressed in immortalized neurons is cleaved near the N-terminus to form N-terminal polypeptides known as cleavage products A and B
Betschart Claudia, Kuhn Rainer, Curtis Daniel, Palacino James, Krainc Dimitri, Jeong Hyunkyung, Valencia Antonio, Masso Nicholas, Sobin Linsday, Bleckmann Dorothee, Reeves Patrick, Alexander Jonathan, Sapp Ellen, Kegel Kimberly B, Sena-Esteves Miguel, Aronin Neil, Paganetti Paolo, DiFiglia Marian   +17 more
doaj   +1 more source

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575) [PDF]

, 2013
PURPOSE: To establish the recommended phase II dose of the oral γ-secretase inhibitor RO4929097 (RO) in combination with gemcitabine; secondary objectives include the evaluation of safety, tolerability, pharmacokinetics, biomarkers of Notch signaling and
Suzanne Richter, Philippe L. Bedard, Eric Xueyu Chen, Blaise A. Clarke, Ben Tran, Sebastien J. Hotte, Anastasios Stathis, Hal W. Hirte, Albiruni R. A. Razak, Michael Reedijk, Zhuo Chen, Brenda Cohen, Wen-Jiang Zhang, Lisa Wang, S. Percy Ivy, Malcolm J. Moore, Amit M. Oza, Lillian L. Siu, Elaine McWhirter, L Miele, V Bolos, S Jarriault, A Klinakis, P Rizzo, J Dufraine, LK Phng, R Plentz, L Luistro, A Tolcher, J Wu, C Moorsel Van, N Cook, P Carmeliet, EA Eisenhauer, W Zhang, DC Allred, BC Dickson, M Reedijk, JR Strosberg, I Krop, TP Dang, W He   +41 more
core   +3 more sources

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease [PDF]

, 2010
: INTRODUCTION: LY450139 (semagacestat) inhibits gamma-secretase, a key enzyme for generation of amyloid beta (Abeta), the peptide deposited in plaques in Alzheimer disease (AD).
Erik Portelius, Robert A Dean, Mikael K Gustavsson, Ulf Andreasson, Henrik Zetterberg, Eric Siemers, Kaj Blennow   +6 more
core   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, EarlyView.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

Neuropsychiatric Disease and Treatment, 2015
Zhiyou Cai,1 Yingjun Zhou,1 Zhou Liu,2,3 Zunyu Ke,1 Bin Zhao2,3 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 2Department of Neurology, The Affiliated Hospital of Guangdong Medical College, 3Institute ...
Cai Z, Zhou Y, Liu Z, Ke Z, Zhao B
doaj  

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and γ-secretase inhibitors

Haematologica, 2010
T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN.
Ana Silva, Patrícia Y. Jotta, André B. Silveira, Daniel Ribeiro, Silvia R. Brandalise, J. Andrés Yunes, João T. Barata   +6 more
doaj   +1 more source