Results 111 to 120 of about 25,969 (247)

Notch1 intracellular domain suppresses APP intracellular domain—Tip60–Fe65 complex mediated signaling through physical interaction [PDF]

, 2007
The amyloid beta-precursor protein (APP) and the Notch receptor are both type 1 integral transmembrane proteins, and both are cleaved by presenilin-dependent gamma-secretase activity.
Kim, Sun-Yee, Kim, Mi-Yeon, Mo, Jung-Soon, Park, Hee-Sae   +3 more
core   +1 more source

Gamma Secretase Inhibitors in Cancer

International Journal of Trends in OncoScience
Gamma secretase inhibitors (GSIs), for Alzheimer's disease treatment, have been repurposed as anticancer agents because they inhibit receptor cleavage. Preclinical studies suggested that GSIs effectively promote the differentiation and apoptosis of cancer stem-like cells while obstructing epithelial-to-mesenchymal transition and increasing sensitivity ...
Dr. V. Aruna, Dr. Anand Mohan Jha, Dr Riffat A Fatima, Dr. Abikesh Prasada Kumar Mahapatra   +3 more
openaire   +1 more source

Novel NOTCH3 alteration expanding the molecular spectrum of pericytic tumours: report of two cases

Histopathology, Volume 88, Issue 4, Page 922-927, March 2026.
Introduction Myofibromas are part of the pericytic tumour family, which includes myopericytomas, glomus tumours and angioleiomyomas. While they typically display benign behaviour when arising in the skin and subcutaneous tissues of the head and neck, rare aggressive variants have been reported, particularly those with visceral or intracranial ...
Irena Antonia Ungureanu, Megane Le Quang, Rihab Azmani, Marie Ancelle, Henri Margot, Guillaume Chotard, François Le Loarer, Nathalène Truffaux   +7 more
wiley   +1 more source

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates [PDF]

, 2006
Background The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of ...
Nyborg Andrew C, Ladd Thomas B, Zwizinski Craig W, Lah James J, Golde Todd E   +4 more
core   +1 more source

A Review of Current Computational Tools for Peptide–Protein Docking

Journal of Computational Chemistry, Volume 47, Issue 5, 15 February 2026.
In this review, we compare 14 specialized peptide‐protein docking programs, adaptable small‐molecule docking tools, and emerging AI‐driven approaches. By clarifying how each method works, we offer researchers an accessible guide to selecting the most suitable tools for biochemical studies and peptide‐focused drug discovery.
Fábio G. Martins, Hélder A. Santos, Sérgio F. Sousa   +2 more
wiley   +1 more source

Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2

Viruses, 2017
Since 2012, our understanding of human papillomavirus (HPV) subcellular trafficking has undergone a drastic paradigm shift. Work from multiple laboratories has revealed that HPV has evolved a unique means to deliver its viral genome (vDNA) to the cell ...
Samuel K. Campos
doaj   +1 more source

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. [PDF]

, 2017
Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of ...
Becker, Ann, Duddy, Steven K, Echmalian, Corinne M, Johnson, Graham, Kim, Doo Y, Klee, Justin B, Lin, Jiunn H, Masliah, Deborah, Mobley, William C, Monte, Louise, Nguyen, Phuong D, Quinti, Luisa, Rissman, Robert A, Rynearson, Kevin D, Tanzi, Rudolph E, Vo, Uyen, Wagner, Steven L, Xia, Weiming, Zhang, Can   +18 more
core   +1 more source

Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava, Lydia Herrmann, Eden Ozkan, Abhiram Kunamneni, Vinamra Swaroop, Geetika Nehra, Rohit Srivastava, Pratima Tripathi, Ken Inoki, Julie E. Goodwin   +9 more
wiley   +1 more source

Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

eLife
Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer’s disease (AD). However, molecular cascades underlying their toxicity are poorly defined.
Katarzyna Marta Zoltowska, Utpal Das, Sam Lismont, Thomas Enzlein, Masato Maesako, Mei CQ Houser, Maria Luisa Franco, Burcu Özcan, Diana Gomes Moreira, Dmitry Karachentsev, Ann Becker, Carsten Hopf, Marçal Vilar, Oksana Berezovska, William Mobley, Lucía Chávez-Gutiérrez   +15 more
doaj   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source