Neurotrophin receptοrs, gamma-secretase inhibitors, and neurodegeneration of basal forebrain cholinergic neurons. [PDF]
Neural Regen Res, 2022 Vilar M.
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Journal of Neurochemistry, Volume 170, Issue 2, February 2026.The interplay between the cholesterol metabolism and assembly of Aβ42 (Amyloid beta‐42) peptide in pathological aggregates is considered one of the major molecular mechanisms in the development of Alzheimer's disease (AD). Our combined studies revealed that Aβ42 was capable of removing cholesterol from the membrane at physiologically relevant low ...
Rishiram Baral +2 more
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The EMBO JournalTwo phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal, i.e. slowing of Alzheimer’s disease (AD) progression.
Bart De Strooper, Eric Karran
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High throughput and targeted screens for prepilin peptidase inhibitors do not identify common inhibitors of eukaryotic gamma-secretase. [PDF]
Expert Opin Drug Discov, 2023 Singh PK, Donnenberg MS.
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USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies
Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge +5 more
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The Potential of Gamma Secretase as a Therapeutic Target for Cardiac Diseases. [PDF]
J Pers Med, 2021 Sen S, Hallee L, Lam CK.
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The Journal of Physiology, Volume 604, Issue 4, Page 1646-1681, 15 February 2026.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
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In vitro effects of gamma-secretase inhibition in HPV-positive and HPV-negative head and neck squamous cell carcinoma. [PDF]
Invest New Drugs, 2023 Varatanovic S +9 more
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Interpreting the spectrum of gamma-secretase complex missense variation in the context of hidradenitis suppurativa-An in-silico study. [PDF]
Front Genet, 2022 Mintoff D, Pace NP, Borg I.
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Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma. [PDF]
Int J Mol Sci, 2022 Abedin Y +8 more
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