Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres. [PDF]
Metabolites, 2022 Singh AK +3 more
europepmc +1 more source
Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations. [PDF]
Int J Mol Sci, 2021 Kim M, Bezprozvanny I.
europepmc +1 more source
Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression. [PDF]
BMC Cancer, 2022 Suzuki S +8 more
europepmc +1 more source
A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma. [PDF]
Clin Cancer Res, 2022 Gounder MM +19 more
europepmc +1 more source
Androgenic hidradenitis suppurativa onset linked to gamma secretase inhibitor. [PDF]
JAAD Case RepTai H +4 more
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Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance. [PDF]
Oncologist, 2021 McCaw TR +7 more
europepmc +1 more source
Repurposing nirogacestat, a gamma secretase enzyme inhibitor in desmoid tumors. [PDF]
Future OncolTansir G, Rastogi S, Gounder MM.
europepmc +1 more source
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia.
Am J Physiol Lung Cell Mol Physiol, 2023 Gwin MS +20 more
europepmc +1 more source