Results 181 to 190 of about 25,969 (247)

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease. [PDF]

Acta Neuropathol Commun
Perrin F, Anderson LC, Mitchell SPC, Sinha P, Turchyna Y, Maesako M, Houser MCQ, Zhang C, Wagner SL, Tanzi RE, Berezovska O.   +10 more
europepmc   +1 more source

Use of an Intramolecular Quenched Fluorescence (IQF) Cleavage Assay for Assessing Enzyme Kinetics of Gamma-Secretase in Human Skin Fibroblasts and Keratinocytes. [PDF]

Methods Mol Biol
Badiei B, Garza LA.
europepmc   +1 more source

Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. [PDF]

J Exp Med, 2020
Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C.   +14 more
europepmc   +1 more source

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites. [PDF]

J Biol Chem
Perrin F, Sinha P, Mitchell SPC, Sadek M, Maesako M, Berezovska O.   +5 more
europepmc   +1 more source

Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. [PDF]

Genetics
Brinkley DM, Smith KC, Fink EC, Kwen W, Yoo NH, West Z, Sullivan NL, Farthing AS, Hale VA, Goutte C.   +9 more
europepmc   +1 more source

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. [PDF]

Bioorg Med Chem, 2020
Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL.   +14 more
europepmc   +1 more source

Altered Regulation of CD46 Expression and Processing in MS [PDF]

, 2010
Astier, Anne, Choileain, Siobhan Ni, So, Magdalene, Weller, Belinda, Weyand, Nathan   +4 more
core   +1 more source

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression [PDF]

, 2019
Bateman, Randall J.
core   +1 more source

A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss. [PDF]

Nat Commun
Schilder AGM, Wolpert S, Saeed S, Middelink LM, Edge ASB, Blackshaw H, REGAIN Consortium, Pastiadis K, Bibas AG.   +8 more
europepmc   +1 more source