Presenilin/γ-secretase and inflammation [PDF]
Frontiers in Aging Neuroscience, 2010 Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
doaj +4 more sources
Assembly, trafficking and function of gamma-secretase [PDF]
Neurodegenerative Diseases, 2006 gamma-Secretase catalyzes the final cleavage of the beta-amyloid precursor protein to generate amyloid-beta peptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer's disease.
Baumeister R +9 more
core +4 more sources
Cellular functions of gamma-secretase-related proteins [PDF]
Neurodegenerative Diseases, 2006 Amyloid-beta pepticle (A beta) is generated by gamma-secretase, a membrane protein complex with an unusual aspartyl protease activity consisting of the four components presenilin, nicastrin, APH-1 and PEN-2. Presenilin is considered the catalytic subunit
Haass, Christian, Haffner, Christof
core +5 more sources
Presenilin-Dependent Gamma-Secretase Activity Modulates Neurite Outgrowth
Neurobiology of Disease, 2002 Demonstration that cleavage of both APP and Notch are dependent on the product of the early onset Alzheimer's disease gene, presenilin-1 (PS1), has raised the possibility that Notch function may be altered in AD. This finding also suggests that Notch may
David J. Figueroa +6 more
doaj +3 more sources
Selective inhibitors of the PSEN1-gamma-secretase complex. [PDF]
J Biol Chem, 2023 Clinical development of γ-secretases, a family of intramembrane cleaving proteases, as therapeutic targets for a variety of disorders including cancer and Alzheimer's disease was aborted because of serious mechanism-based side effects in the phase III trials of unselective inhibitors.
Serneels L +12 more
europepmc +7 more sources
gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes. [PDF]
PLoS ONE, 2010 BACKGROUND: gamma-Secretase is an intramembrane aspartyl protease whose cleavage of the amyloid precursor protein (APP) generates the amyloid beta-peptide (Abeta) and the APP intracellular domain.
Jenny Frånberg +4 more
doaj +1 more source
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter +6 more
core +2 more sources
Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. [PDF]
PLoS ONE, 2009 Presenilin 1(PS1) is the catalytic subunit of gamma-secretase, the enzyme responsible for the Abeta C-terminal cleavage site, which results in the production of Abeta peptides of various lengths.
Kengo Uemura +9 more
doaj +1 more source
Role of cholesterol in substrate recognition by $$\gamma$$ γ -secretase
Scientific Reports, 2021 $$\gamma$$ γ -Secretase is an enzyme known to cleave multiple substrates within their transmembrane domains, with the amyloid precursor protein of Alzheimer’s Disease among the most prominent examples.
Łukasz Nierzwicki +3 more
doaj +1 more source
Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis. [PDF]
PLoS ONE, 2008 BACKGROUND: Atherosclerosis is a common multifactorial disease resulting from an interaction between susceptibility genes and environmental factors. The causative genes that contribute to atherosclerosis are elusive.
Karen M J van Loo +6 more
doaj +1 more source