Results 211 to 220 of about 25,969 (247)

Gamma-secretase: never more enigmatic.

Trends in neurosciences, 2002
It is widely believed that the pathogenesis of Alzheimer's disease (AD) is intimately, if not causatively, associated with the deposition of approximately 4 kDa beta-amyloid (A beta) peptides in the cerebral cortex and hippocampus of affected individuals. A beta peptides are liberated from transmembrane proteins, termed beta-amyloid precursor proteins (
S S, Sisodia, W, Annaert, S H, Kim, B, De Strooper   +3 more
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gamma-Secretase modulators.

Current Alzheimer research, 2008
gamma-Secretase is responsible for the final cut of the amyloid beta-peptide (Abeta) precursor (APP) to produce the Abeta peptide implicated the pathogenesis of Alzheimer's disease (AD). Thus, this protease is a top target for the development of AD therapeutics.
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[Beta- and gamma-secretases].

Rinsho shinkeigaku = Clinical neurology, 2007
Deposition of amyloid beta peptides (Abeta) as amyloid deposits characterizes the brains of patients with Alzheimer's disease (AD). Mutations in presenilin genes linked to familial AD (FAD) have been shown to increase production of Abeta42, an initially and predominantly depositing Abeta species in all types of AD.
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Advances in gamma-secretase modulation.

Current opinion in drug discovery & development, 2007
Inhibition of the production of insoluble amyloid-Beta (ABeta) is a widely pursued strategy for the treatment of Alzheimer's disease (AD). The final step in the generation of ABeta from the amyloid precursor protein (APP) involves cleavage by gamma-secretase, and gamma-secretase inhibitors (GSIs) have been shown to reduce the amyloid burden in animal ...
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Development of Specific Gamma Secretase Inhibitors

2009
Secretases are aspartic proteases, which specifically trim important, medically relevant targets such as the amyloid-precursor protein (APP) or the Notch-receptor. Therefore, changes in their activity can lead to dramatic diseases like M. Alzheimer caused by aggregation of peptidic fragments.
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Presenilin function and gamma-secretase activity.

Journal of neurochemistry, 2005
Alzheimer's disease (AD) is the most common form of dementia and is characterized pathologically by the accumulation of beta-amyloid (Abeta) plaques and neurofibrillary tangles in the brain. Genetic studies of AD first highlighted the importance of the presenilins (PS).
A L, Brunkan, A M, Goate
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Gamma Secretase

2007
Sharie Haugabook, Kumar Sambamurti
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Identity and function of gamma-secretase.

Journal of neuroscience research, 2003
gamma-Secretase catalyzes intramembrane proteolysis of various type I membrane proteins, including the amyloid-beta precursor protein and the Notch receptor. Despite its importance in the pathogenesis of Alzheimer's disease and to normal development, this protease has eluded identification until only very recently.
W Taylor, Kimberly, Michael S, Wolfe
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Gamma-secretase inhibitors and Alzheimer's disease.

Advanced drug delivery reviews, 2003
The existence of pathogenic mutations in beta-APP and the presenilin genes provides strong support for the hypothesis that Abeta production and deposition contribute to the etiology of Alzheimer's disease (AD). The heterogeneous carboxyl termini of Abeta molecules deposited in the hippocampus, cortex and cerebrovasculature of AD patients are generated ...
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gamma-Secretase in biology and medicine.

Seminars in cell & developmental biology, 2009
gamma-Secretase is a membrane-embedded proteolytic complex composed of presenilin and three other subunits. The gamma-secretase complex generates the amyloid beta-peptide of Alzheimer's disease but also plays important roles in normal physiology, especially in signaling from the Notch receptor.
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